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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 160 - 167 (8page)
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초록· 키워드
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Nypa fruticans Wurmb (NFW) contains a large amount of phenolic acid and flavonoids, and is popular as a superfood in Myanmar. NFW has various biological activities, such as anti-inflammatory, anti-oxidant, and neuroprotective properties; however, the anti-cancer effect of NFW have not been reported. In this study, we investigated the anticancer activity of water extracts of NFW (WeNFW) and the underlying mechanism in human FaDu hypopharyngeal squamous carcinoma cells. The WeNFW inhibited FaDu cell growth in a dose-dependent manner without affecting normal cells (L929), as determined by an MTT assay and Live and Dead assay. In addition, the concentrations of WeNFW without cytotoxicity (0.025, 0.05, and 0.1 mg/mL) inhibited wound healing and colony formation. Furthermore, WeNFW significantly induced apoptosis through the proteolytic cleavage of caspase-3 and -9, poly (ADP-ribose) polymerase, and downregulation of Bcl-2 and upregulation of Bax in FaDu cells, as determined by DAPI staining, FACS analysis, and western blot analysis. Taken together, these results suggest that WeNFW exhibits potent anti-cancer effects by suppressing the growth of oral cancer cells, wound healing and colony formation activity. Via mitrochondrial-dependent apoptotic pathways in human FaDu hypopharyngeal squamous carcinoma cells. Therefore, WeNFW can provide a natural chemotherapeutic drug for oral cancer in humans.
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참고문헌 (27)
참고문헌 신청
Robinson KL / 2003 / Oropharyngeal cancer incidence and mortality in Scotland : are rates still increasing / Oral Oncol 39:31~36
Canto MT / 2002 / Oral cavity and pharynx cancer incidence rates in the United States, 1975-1998 / Oral Oncol 38:610~617
한지형 / 2012 / 구강암의 발생현황과 원인 / 치위생과학회지 12(5):451~458
Kumar M / 2016 / Oral cancer : etiology and risk factors : a review / J Cancer Res Ther 12:458~463
Marcazzan S / 2018 / Nanomedicine, an emerging therapeutic strategy for oral cancer therapy / Oral Oncol 76:1~7
Canto MT / 2002 / Oral cavity and pharynx cancer incidence rates in the United States, 1975-1998 / Oral Oncol 38:610~617
한지형 / 2012 / 구강암의 발생현황과 원인 / 치위생과학회지 12(5):451~458
Kumar M / 2016 / Oral cancer : etiology and risk factors : a review / J Cancer Res Ther 12:458~463
Marcazzan S / 2018 / Nanomedicine, an emerging therapeutic strategy for oral cancer therapy / Oral Oncol 76:1~7
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