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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 43 - 49 (7page)
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초록· 키워드
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Tannic acid (TA) is a water-soluble polyphenol compound found in various herbal plants. We investigated the chemopreventive effects of TA on FaDu hypopharyngeal squamous carcinoma cells. In an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, TA showed dose-dependent cytotoxicity with a half maximal inhibitory concentration (IC50) of 50 µM. Cell cycle analysis and immunofluorescence imaging demonstrated that under low-dose (25 µM) treatment, FaDu cells were arrested in G2/M phase, and as the dose of TA was increased, apoptosis was induced with the increase of cell population at sub-G1 phase. The expressions of various cyclins, including cyclin D1 and cyclin-dependent kinases (CDK-1 and CDK-2), were down-regulated at low doses of TA, whereas apoptotic effectors such as cleaved caspase 3, cleaved caspase 7, and poly (ADP-ribose) polymerase (PARP) were expressed in a dose-dependent manner in Western blotting. In addition, TA-induced apoptosis of FaDu cells might be mediated by the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase pathway, with the upregulation of p-AKT/p-PKB (phosphorylated protein kinase B) and p-ERK. Overall, our data support the hypothesis that TA is a potential candidate agent for the treatment of hypopharyngeal cancer.
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참고문헌 (29)
참고문헌 신청
R J Sanderson / 2002 / Squamous cell carcinomas of the head and neck * Commentary: Head and neck carcinomas in the developing world / BMJ 325(7368):822~827
Lindsey A. Torre / 2015 / Global cancer statistics, 2012 / CA: A Cancer Journal for Clinicians 65(2):87~108
Ewa Majchrzak / 2014 / Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature / Radiology and Oncology 48(1):1~10
Negri E / 1993 / Attributable risk for oral cancer in northern Italy / Cancer Epidemiol Biomarkers Prev 2:189~193
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans / 2004 / Tobacco smoke and involuntary smoking / IARC Monogr Eval Carcinog Risks Hum 83:1~1438
Lindsey A. Torre / 2015 / Global cancer statistics, 2012 / CA: A Cancer Journal for Clinicians 65(2):87~108
Ewa Majchrzak / 2014 / Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature / Radiology and Oncology 48(1):1~10
Negri E / 1993 / Attributable risk for oral cancer in northern Italy / Cancer Epidemiol Biomarkers Prev 2:189~193
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans / 2004 / Tobacco smoke and involuntary smoking / IARC Monogr Eval Carcinog Risks Hum 83:1~1438
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