지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 331 - 344 (14page)
- DOI
- https://doi.org/10.4250/jcvi.2020.0216
이용수
초록· 키워드
오류제보하기
BACKGROUND: Myocardial deformation with echocardiography allows early detection of systolic dysfunction and is related to myocardial iron overload (MIO) determined by T2* in hereditary anemias under transfusion support. Our aim was to analyze the diagnostic and prognostic usefulness of magnetic resonance feature tracking (MR-FT) myocardial strain in low-risk myelodysplastic syndromes (LR-MDS) patients. METHODS: Prospective study in transfusion-dependent LR-MDS patients and healthy controls who underwent a cardiac MR-FT. We analyzed the relationships between strain MR-FT and iron overload parameters and its prognostic impact in cardiovascular events and/or death. RESULTS: Thirty-one patients and thirteen controls were included. MIO (T2* < 20 ms) was detected in 9.7% of patients. Left ventricular global longitudinal strain (LV-GLS) by MR-FT was pathological (> ?19.3%) in 32.3% of patients. Less negative strain values correlated with lower T2* (R = ?0.37, p = 0.033) and native myocardial T1 (R = ?0.39, p = 0.031) times. LV-GLS by MR-FT was significantly associated with higher incidence of the combined cardiovascular events and/or all-cause death (p = 0.047), with a cut-off value of ?17.7% for predicting them (63% sensitivity and 81% specificity, area under the curve = 0.69). After adjusting analysis including demographic, biomarkers and imaging variables, a higher LV-GLS value by MR-FT remained as predictor of combined event in transfusion-dependent LR-MDS patients (hazard ratio, 0.4; confidence interval, 0.15?0.98; p = 0.045). CONCLUSIONS: Longitudinal myocardial strain by MR-FT in LR-MDS patients is associated to MIO and correlates with adverse events in the follow-up, what could serve as a prognostic tool.
목차
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참고문헌 (30)
참고문헌 신청
Remacha ÁF / 2015 / Evolution of iron overload in patients with low-risk myelodysplastic syndrome : iron chelation therapy and organ complications / Ann Hematol 94:779~787
Goldberg SL / 2010 / Incidence and clinical complications of myelodysplastic syndromes among United States Medicare beneficiaries / J Clin Oncol 28:2847~2852
Lyons RM / 2017 / Relation between chelation and clinical outcomes in lower-risk patients with myelodysplastic syndromes : registry analysis at 5 years / Leuk Res 56:88~95
Roy NB / 2011 / Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes / Br J Haematol 154:521~524
Gujja P / 2010 / Iron overload cardiomyopathy : better understanding of an increasing disorder / J Am Coll Cardiol 56:1001~1012
Goldberg SL / 2010 / Incidence and clinical complications of myelodysplastic syndromes among United States Medicare beneficiaries / J Clin Oncol 28:2847~2852
Lyons RM / 2017 / Relation between chelation and clinical outcomes in lower-risk patients with myelodysplastic syndromes : registry analysis at 5 years / Leuk Res 56:88~95
Roy NB / 2011 / Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes / Br J Haematol 154:521~524
Gujja P / 2010 / Iron overload cardiomyopathy : better understanding of an increasing disorder / J Am Coll Cardiol 56:1001~1012
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