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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 521 - 524 (4page)
- DOI
- https://doi.org/10.4306/pi.2017.14.4.521
이용수
초록· 키워드
오류제보하기
With recent advancement in amyloid imaging, diagnostic application of this new modality has become a great interest among researchers. New ligands, such as 18F- florbetaben, florbetapir and flutemetamol, have been discovered to overcome limitations of preexisting ligand Pittsburgh compound B. We report here a case of a 37-year-old male patient whose initial complaints comprised of gradual cognitive decline, apraxia, disorientation and sleep disturbances. 18F-Florbetaben amyloid imaging of the patient showed diffuse amyloid retention with prominent striatal uptake. This finding supports the clinical utility of amyloid imaging in diagnostic process of early-onset AD. Moreover, striatal dominant uptake pattern demonstrated in this patient include some meaningful clinical implications that warrant special attention among clinicians.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Selkoe DJ / 2016 / The amyloid hypothesis of Alzheimer’s disease at 25 years / EMBO Mol Med 8:595~608
Jack CR Jr / 2010 / Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade / Lancet Neurol 9:119~128
Rabinovici GD / 2015 / The translational journey of brain β-amyloid imaging : from positron emission tomography to autopsy to clinic / JAMA Neurol 72:265~266
Bensaïdane MR / 2016 / Clinical Utility of Amyloid PET Imaging in the Differential Diagnosis of Atypical Dementias and Its Impact on Caregivers / J Alzheimers Dis 52:1251~1262
Klunk WE / 2004 / Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B / Ann Neurol 55:306~319
Jack CR Jr / 2010 / Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade / Lancet Neurol 9:119~128
Rabinovici GD / 2015 / The translational journey of brain β-amyloid imaging : from positron emission tomography to autopsy to clinic / JAMA Neurol 72:265~266
Bensaïdane MR / 2016 / Clinical Utility of Amyloid PET Imaging in the Differential Diagnosis of Atypical Dementias and Its Impact on Caregivers / J Alzheimers Dis 52:1251~1262
Klunk WE / 2004 / Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B / Ann Neurol 55:306~319
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