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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 883 - 886 (4page)
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초록· 키워드
오류제보하기
Objective: Recently developed 18F-labelled amyloid beta (Aβ) positron emission tomography (PET) tracers have demonstrated potentials to enable more prevalent application of amyloid imaging in the clinical setting. The aim of this study is to demonstrate cerebral retention of Aβ in cognitively normal older adults, by implementing voxel-based analysis on images acquired from 18F-Florbetaben amyloid PET.
Methods: Fifty cognitive normal elderly subjects were recruited and included in the study. Demographic data and cognitive measurements were collected. Magnetic resonance imaging (MRI) and 18F-Florbetaben PET data were obtained followed by whole brain voxel-based analysis.
Results: Compared to the florbetaben (FBB) (-) counterpart, FBB (+) showed significantly higher Aβ deposition in the brain regions comprising anterior cingulate, middle cingulate, posterior cingulate and precuneus (family wise error corrected p<0.05). There was no significant correlation between amyloid retention and cognitive functions.
Conclusion: Our results confirms previous results regarding Aβ deposition by using 18F-Florbetaben, demonstrating potentials in application of 18F-Florbetaben PET imaging in clinical settings.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Aizenstein HJ / 2008 / Frequent amyloid deposition without significant cognitive impairment among the elderly / Arch Neurol 65 : 1509 ~ 1517
Ashburner J / 2005 / Unified segmentation / Neuroimage 26 : 839 ~ 851
Cohen AD / 2009 / Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment : an example of brain reserve / J Neurosci 29 : 14770 ~
Greicius M / 2008 / Resting-state functional connectivity in neuropsychiatric disorders / Curr Opin Neurol 21 : 424 ~ 430
Hanseeuw B / 2016 / Patients with amyloid-negative mild cognitive impairment have cortical hypometabolism but the hippocampus is preserved / J Alzheimers Dis 53 : 651 ~ 660
Ashburner J / 2005 / Unified segmentation / Neuroimage 26 : 839 ~ 851
Cohen AD / 2009 / Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment : an example of brain reserve / J Neurosci 29 : 14770 ~
Greicius M / 2008 / Resting-state functional connectivity in neuropsychiatric disorders / Curr Opin Neurol 21 : 424 ~ 430
Hanseeuw B / 2016 / Patients with amyloid-negative mild cognitive impairment have cortical hypometabolism but the hippocampus is preserved / J Alzheimers Dis 53 : 651 ~ 660
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