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논문 기본 정보

자료유형
학술저널
저자정보
Huseyin Bayazit (Siverek State Hospital) Salih Selek (University of Texas) Ibrahim Fatih Karababa (Harran University School of Medicine) Erdinc Cicek (Çumra State Hospital) Nurten Aksoy (Harran University)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제3호
발행연도
2017.8
수록면
237 - 242 (6page)
DOI
https://doi.org/10.9758/cpn.2017.15.3.237

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Objective: Cannabis is the most commonly used illegal drug in the world and it has several adverse effects such as anxiety, panic reactions and psychotic symptoms. In this study, we aimed to evaluate oxidant, anti-oxidant status and cytokine levels in individuals with cannabis use disorder. Methods: Thirty-four patients with cannabis use disorder and 34 healthy controls were enrolled to the study. Serum total antioxidant status, total oxidant status and cytokine levels were investigated in patients with cannabis use disorder and healthy controls. Results: We found increased levels of total oxidant status, oxidative stress index and interleukin (IL) 1?, IL-6, IL-8, and tumor necrosis factor (TNF) ? in individuals with cannabis dependency compared to healthy people. When we compared total antioxidant status, IL-12, and interferon (IFN) ? levels, there were no differences in both groups. There was positive correlation between IL-6 and total oxidant status, oxidative stress index levels. Conclusion: The oxidative balance of individuals with cannabis use disorder was impaired and they had higher levels of IL-1?, IL-6, IL-8, and TNF-?, which is a pro-inflammatory cytokine and indicates increased inflammation compared to healthy controls. Thus, these findings suggest that cannabis increased inflammation and impaired the oxidative balance.

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