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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 422 - 426 (5page)
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초록· 키워드
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Background: Although phenotypic heterogeneity of psoriasis is suggested by the alternate activation of either T-helper (Th)1-related or Th17-related cytokines, little is known about the mRNA levels of inflammatory cytokines. Objective: To investigate whether there is differential expression of Th1-related and Th17-related inflammatory cytokine genes 1) between psoriatic patients and healthy controls, and 2) between patients with different psoriasis phenotypes. Methods: Twenty-five patients with psoriasis (10 with guttate psoriasis and 15 with plaque psoriasis) and 5 healthy volunteers were enrolled in this study. The mRNA levels of circulating cytokines (interleukin [IL]-2, IL-12p40, interferon-γ, IL-17A, IL-22, and IL-23R) were measured by real-time reverse transcription polymerase chain reaction. Results: The comparison between psoriatic and healthy control samples revealed that IL-12p40, IL-17A, and IL-22 mRNA levels were significantly higher (approximately 4∼6 folds) in the patients with psoriasis. The mRNA levels of these six cytokines in the blood did not differ between the guttate and plaque psoriasis groups. Conclusion: We found that the mRNA levels of blood inflammatory cytokines (IL-12p40, IL-17A, and IL-22) were significantly elevated in patients with psoriasis compared to the levels in healthy controls, but they did not significantly differ between patients with guttate and plaque type psoriasis.
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참고문헌 (18)
참고문헌 신청
Bos JD / 1988 / The pathomechanisms of psoriasis; the skin immune system and cyclosporin / Br J Dermatol 118 : 141 ~ 155
Choe YB / 2012 / A comparison of serum inflammatory cytokines according to phenotype in patients with psoriasis / Br J Dermatol 167 : 762 ~ 767
Christophers E / 2008 / Explaining phenotype heterogeneity in patients with psoriasis / Br J Dermatol 158 : 437 ~ 441
Gomi T / 1991 / Interleukin 1 alpha, tumor necrosis factor alpha, and interferon gamma in psoriasis / Arch Dermatol 127 : 827 ~ 830
Griffiths CE / 2007 / A classification of psoriasis vulgaris according to phenotype / Br J Dermatol 156 : 258 ~ 262
Choe YB / 2012 / A comparison of serum inflammatory cytokines according to phenotype in patients with psoriasis / Br J Dermatol 167 : 762 ~ 767
Christophers E / 2008 / Explaining phenotype heterogeneity in patients with psoriasis / Br J Dermatol 158 : 437 ~ 441
Gomi T / 1991 / Interleukin 1 alpha, tumor necrosis factor alpha, and interferon gamma in psoriasis / Arch Dermatol 127 : 827 ~ 830
Griffiths CE / 2007 / A classification of psoriasis vulgaris according to phenotype / Br J Dermatol 156 : 258 ~ 262
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