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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,021 - 1,033 (13page)
- DOI
- 10.1007/s13770-021-00381-w
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초록· 키워드
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BACKGROUND: Osteoporosis is a systemic bone disease characterized by decreased bone density and deterioration of bone microstructure, leading to an increased probability of fragility fractures. Once segmental bone defect occurs, it is easy to cause delayed union and nonunion.
METHODS: The aim of this study is to investigate the efficacy of extracorporeal shock wave (ESW) and teriparatide-loaded hydrogel (T-Gel) combined strategy on the cell activity and differentiation of osteoporosis derived bone marrow mesenchymal stem cells (OP-BMSCs) in vitro and bone regeneration in osteoporotic segmental bone defects in vivo.
RESULTS: In vitro, the strategy of combining ESW and T-Gel significantly enhanced OP-BMSCs proliferation, survival, migration, and osteogenic differentiation by up-regulating the alkaline phosphatase activity, mineralization, and expression of runt-related transcription factor-2, type I collagen, osteocalcin, and osteopontin. In the segmental bone defect models of osteoporotic rabbits, Micro-CT evaluation and histological observation demonstrated this ESW-combined with T-Gel injection significantly induced bone healing by enhancing the osteogenic activity of the local microenvironment in osteoporotic defects.
CONCLUSION: In conclusion, ESW-combined with T-Gel injection could regulate the poor osteogenic microenvironment in osteoporotic defects and show potential for enhancing fragility fractures healing.
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참고문헌 (42)
참고문헌 신청
Porwal K / 2021 / Therapeutic potential of phosphodiesterase inhibitors in the treatment of osteoporosis : Scopes for therapeutic repurposing and discovery of new oral osteoanabolic drugs / Eur J Pharmacol 899:174015
Hampson G / 2021 / A review and perspective on the assessment, management and prevention of fragility fractures in patients with osteoporosis and chronic kidney disease / Endocrine 73:509~529
Zhang C / 2021 / Dental implants loaded with bioactive agents promote osseointegration in osteoporosis : a review / Front Bioeng Biotechnol 9:591796
Russow G / 2019 / Anabolic therapies in osteoporosis and bone regeneration / Int J Mol Sci 20:83
Bottai V / 2015 / Total hip replacement in osteoarthritis : the role of bone metabolism and its complications / Clin Cases Miner Bone Metab 12:247~250
Hampson G / 2021 / A review and perspective on the assessment, management and prevention of fragility fractures in patients with osteoporosis and chronic kidney disease / Endocrine 73:509~529
Zhang C / 2021 / Dental implants loaded with bioactive agents promote osseointegration in osteoporosis : a review / Front Bioeng Biotechnol 9:591796
Russow G / 2019 / Anabolic therapies in osteoporosis and bone regeneration / Int J Mol Sci 20:83
Bottai V / 2015 / Total hip replacement in osteoarthritis : the role of bone metabolism and its complications / Clin Cases Miner Bone Metab 12:247~250
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