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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치과보철학회 The Journal of Advanced of Prosthodontics The Journal of Advanced of Prosthodontics 제9권 제3호
- 발행연도
- 2017.6
- 수록면
- 217 - 223 (7page)
- DOI
- https://doi.org/10.4047/jap.2017.9.3.217
이용수
초록· 키워드
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PURPOSE. This study investigated the effects of silver nanoparticle (SN) loading into hydraulic calcium silicatebased Portland cement on its mechanical, antibacterial behavior and biocompatibility as a novel dental bone substitute.
MATERIALS AND METHODS. Chemically reduced colloidal SN were combined with Portland cement (PC) by the concentrations of 0 (control), 1.0, 3.0, and 5.0 wt%. The physico-mechanical properties of silver-Portland cement nanocomposites (SPNC) were investigated through X-ray diffraction (XRD), setting time, compressive strength, solubility, and silver ion elution. Antimicrobial properties of SPNC were tested by agar diffusion against Streptococcus mutans and Streptococcus sobrinus. Cytotoxic evaluation for human gingival fibroblast (HGF) was performed by MTS assay.
RESULTS. XRD certified that SN was successfully impregnated in PC. SPNC at above 3.0 wt% significantly reduced both initial and final setting times compared to control PC. No statistical differences of the compressive strength values were detected after SN loadings, and solubility rates of SPNC were below 3.0%, which are acceptable by ADA guidelines. Ag ion elutions from SPNC were confirmed with dose-dependence on the concentrations of SN added. SPNC of 5.0 wt% inhibited the growth of Streptococci, whereas no antimicrobial activity was shown in control PC. SPNC revealed no cytotoxic effects to HGF following ISO 10993 (cell viability > 70%).
CONCLUSION. Addition of SN promoted the antibacterial activity and favored the bio-mechanical properties of PC; thus, SPNC could be a candidate for the futuristic dental biomaterial. For clinical warrant, further studies including the inhibitory mechanism, in vivo and longterm researches are still required.
목차
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참고문헌 (42)
참고문헌 신청
Berberi A / 2014 / Physicochemical characteristics of bone substitutes used in oral surgery in comparison to autogenous bone / Biomed Res Int 2014:320790
김영균 / 2014 / Alveolar ridge preservation of an extraction socket using autogenous tooth bone graft material for implant site development: prospective case series / The Journal of Advanced of Prosthodontics 6(6):521~527
Wynn-Jones G / 2012 / Development of Portland cement for orthopedic applications, establishing injectability and decreasing setting times / J Biomed Mater Res B Appl Biomater 100:2213~2221
Peh WC / 2008 / Percutaneous vertebral augmentation: vertebroplasty, kyphoplasty and skyphoplasty / Radiol Clin North Am 46:611~635
Torabinejad M / 1993 / Sealing ability of a mineral trioxide aggregate when used as a root end filling material / J Endod 19:591~595
김영균 / 2014 / Alveolar ridge preservation of an extraction socket using autogenous tooth bone graft material for implant site development: prospective case series / The Journal of Advanced of Prosthodontics 6(6):521~527
Wynn-Jones G / 2012 / Development of Portland cement for orthopedic applications, establishing injectability and decreasing setting times / J Biomed Mater Res B Appl Biomater 100:2213~2221
Peh WC / 2008 / Percutaneous vertebral augmentation: vertebroplasty, kyphoplasty and skyphoplasty / Radiol Clin North Am 46:611~635
Torabinejad M / 1993 / Sealing ability of a mineral trioxide aggregate when used as a root end filling material / J Endod 19:591~595
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