지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Antimicrobial technologies, including silver-containing medical devices, are increasingly utilized in clinical regimens to mitigate risks of microbial colonization. Silver-functionalized resorbable biomaterials for use in wound management and tissue regeneration applications have a narrow therapeutic index where antimicrobial effectiveness may be outweighed by adverse cytotoxicity. We examined the effects of ionic silver functionalization of an extracellular matrix (ECM) biomaterial derived from ovine forestomach (OFM-Ag) in terms of material properties, antimicrobial effectiveness and cytotoxicity profile. Methods: Material properties of OFM-Ag were assessed by via biochemical analysis, microscopy, atomic absorption spectroscopy (AAS) and differential scanning calorimetry. The silver release profile of OFM-Ag was profiled by AAS and antimicrobial effectiveness testing utilized to determine the minimum effective concentration of silver in OFMAg in addition to the antimicrobial spectrum and wear time. Biofilm prevention properties of OFM-Ag in comparison to silver containing collagen dressing materials was quantified via in vitro crystal violet assay using a polymicrobial model. Toxicity of ionic silver, OFM-Ag and silver containing collagen dressing materials was assessed toward mammalian fibroblasts using elution cytoxicity testing. Results: OFM-Ag retained the native ECM compositional and structural characteristic of non-silver functionalized ECM material while imparting broad spectrum antimicrobial effectiveness toward 11 clinically relevant microbial species including fungi and drug resistant strains, maintaining effectiveness over a wear time duration of 7-days. OFM-Ag demonstrated significant prevention of polymicrobial biofilm formation compared to non-antimicrobial and silver-containing collagen dressing materials. Where silver-containing collagen dressing materials exhibited cytotoxic effects toward mammalian fibroblasts, OFM-Ag was determined to be non-cytotoxic, silver elution studies indicated sustained retention of silver in OFM-Ag as a possible mechanism for the attenuated cytotoxicity. Conclusions: This work demonstrates ECM biomaterials may be functionalized with silver to favourably shift the balance between detrimental cytotoxic potential and beneficial antimicrobial effects, while preserving the ECM structure and function of utility in tissue regeneration applications.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of the Ag₃PO₄ on Staphylococcus aureus Growth and Human Immunity
대한의생명과학회지
2018 .03
-
Superior absorption and retention properties of foam-film silver dressing versus other commercially available silver dressing
생체재료학회지
2016 .12
-
Biogenic fabrication and characterization of silver nanoparticles using aqueous-ethanolic extract of lichen (Usnea longissima) and their antimicrobial activity
생체재료학회지
2018 .12
-
Dimension-dependent toxicity of silver nanomaterials to organism
환경독성보건학회 심포지엄 및 학술대회
2015 .10
-
Antibacterial activity and characterization of tissue conditioner containing silver-chitosan nanocomplex
대한치과재료학회지
2020 .06
-
Evaluation of the cell viability and antimicrobial effects of orthodontic bands coated with silver or zinc oxide nanoparticles: An in vitro study
대한치과교정학회지
2023 .01
-
Erratum to: Superior absorption and retention properties of foam-film silver dressing versus other commercially available silver dressing
생체재료학회지
2016 .12
-
Silver nanoparticles–decorated extracellular matrix graft: fabrication and tendon reconstruction performance
생체재료학회지
2023 .03
-
Ag의 함량에 따른 Ag-Pd-In계 합금의 광학적 특성 및 미세구조의 변화
대한치과재료학회지
2018 .09
-
Ecotoxicity test of Daphnia magna exposed to silver nanoparticle and nanowire
환경독성보건학회 심포지엄 및 학술대회
2015 .06
-
Biocompatible Ti3Au–Ag/Cu thin film coatings with enhanced hardness and antimicrobial functionality
생체재료학회지
2023 .03
-
Characterization of tissue conditioner containing chitosan-doped silver nanoparticles
대한치과보철학회지
2020 .01
-
Silver nanoparticles in endodontics: recent developments and applications
Restorative Dentistry and Endodontics
2021 .08
-
Mobility of silver nanoparticles in saturated porous media : The effects of ionic strength, pH and clay
환경독성보건학회 심포지엄 및 학술대회
2015 .06
-
Antibacterial potency of different deposition methods of silver and copper containing diamond-like carbon coated polyethylene
생체재료학회지
2016 .09
-
적절한 항균제 선택의 원칙
대한의사협회지
2019 .01
-
Efficacy of silver ions against Sacbrood virus infection in the Eastern honey bee Apis cerana
Journal of Veterinary Science
2015 .09
-
알테미아 살리나종을 이용한 은나노물질의 급성독성평가
환경독성보건학회 심포지엄 및 학술대회
2017 .10
-
Antimicrobial Consumption as a Key Component of Antimicrobial Stewardship Programs: a Meaningful Movement toward Evidence-based Antimicrobial Stewardship of Validated Outcome Measures
Journal of Korean Medical Science
2020 .01
-
Evaluation of the Remineralization Capacity of Water-based Silver Fluoride
대한소아치과학회지
2024 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0