흰쥐에서 파모티딘과 모사프리드 병합 투여가 위내 pH와 위배출에 미치는 영향

Hyun Seok Choi; Eui Joong Kim; Min Seob Kim; Ji Yeon Myung; Myeong Hwan Yu; Yong Sung Kim; 이문영

doi:10.7704/kjhugr.2021.0013

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저자정보: Hyun Seok Choi (Department of Physiology Wonkwang University School of Medicine) Eui Joong Kim (Department of Physiology Wonkwang University School of Medicine) Min Seob Kim (Department of Physiology Wonkwang University School of Medicine) Ji Yeon Myung (Department of Physiology Wonkwang University School of Medicine) Myeong Hwan Yu (Department of Physiology Wonkwang University School of Medicine) Yong Sung Kim (Department of Physiology Wonkwang University School of Medicine) 이문영 (원광대학교)

저널정보: 대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research Vol.21 No.3

발행연도: 2021.9

수록면: 220 - 225 (6page)

DOI: 10.7704/kjhugr.2021.0013

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Background/Aims: Studies in healthy humans have reported that the addition of mosapride to acid suppressants resulted in higher intragastric pH than acid suppressant administration alone. We investigated the effect of the addition of mosapride to famotidine on the intragastric pH and gastric emptying rate (GER) in rats. Materials and Methods: Sixty male Wistar rats were used in this study. Experimental groups were divided into control, famotidine- only, mosapride-only, and famotidine with mosapride (combination). The first experiment was performed in non-stressed rats. Mosapride was administered by oral gavage 1 hour before the meal, and famotidine was administered just before the meal. The rats were provided with food for 30 minutes. The intragastric pH was measured under isoflurane anesthesia, and the GER was measured after harvesting the stomach. In the stress experiment, rats were exposed to 1-hour restraint stress immediately after mosapride administration and subjected to the same process as in the experiment with the non-stressed rats. Results: The famotidine-only and combination groups showed significantly higher gastric pH levels than the control group in non-stressed (P<0.01 and P<0.001, respectively) and stressed (P<0.001 and P<0.001, respectively) rats. The combination group also showed significantly higher intragastric pH levels than the famotidine-only group in non-stressed (P<0.01) and stressed (P<0.05) rats. Additionally, combination groups showed a significantly higher GER than the famotidine-only group in non-stressed (P<0.001) and stressed (P<0.01) rats. Conclusions: The combination of mosapride with famotidine significantly increased intragastric pH compared to famotidine alone in the non-stressed and stressed rats.

#Famotidine #Gastric acid #Gastric emptying #Mosapride #Stress #Psychological

참고문헌 (22)

참고문헌 신청

심영광 / 2017 / H2 수용체 길항제의 위산분비 억제 효과 및 임상적 응용 / 대한소화기학회지 70(1):4~12

Lubach JW / 2013 / Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans / Mol Pharm 10:3997~4004

Ikawa K / 2007 / Pharmacokinetic and pharmacodynamic properties of lafutidine after postprandial oral administration in healthy subjects: comparison with famotidine / Biol Pharm Bull 30:1003~1006

Sachs G / 2014 / Gastric acid-dependent diseases : a twentieth-century revolution / Dig Dis Sci 59:1358~1369

James LP / 1996 / Pharmacokinetics and pharmacodynamics of famotidine in paediatric patients / Clin Pharmacokinet 31:103~110

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