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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 285 - 298 (14page)
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The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface markers provide molecular targeted therapies for various cancers, using therapeutic antibodies specific for the CSC surface markers. Various CSC surface markers have been identified and published. Interestingly, most of the markers used to identify CSCs are derived from surface markers present on human embryonic stem cells (hESCs) or adult stem cells. In this review, we classify the currently known 40 CSC surface markers into 3 different categories, in terms of their expression in hESCs, adult stem cells, and normal tissue cells. Approximately 73% of current CSC surface markers appear to be present on embryonic or adult stem cells, and they are rarely expressed on normal tissue cells. The remaining CSC surface markers are considerably expressed even in normal tissue cells, and some of them have been extensively validated as CSC surface markers by various research groups. We discuss the significance of the categorized CSC surface markers, and provide insight into why surface markers on hESCs are an attractive source to find novel surface markers on CSCs.
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참고문헌 (166)
참고문헌 신청
Visvader JE / 2008 / Cancer stem cells in solid tumours: accumulating evidence and unresolved questions / Nat Rev Cancer 8:755~768
Tirino V / 2013 / Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization / FASEB J 27:13~24
Bonnet D / 1997 / Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell / Nat Med 3:730~737
Al-Hajj M / 2003 / Prospective identification of tumorigenic breast cancer cells / Proc Natl Acad Sci U S A 100:3983~3988
Singh SK / 2004 / Identification of human brain tumour initiating cells / Nature 432:396~401
Tirino V / 2013 / Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization / FASEB J 27:13~24
Bonnet D / 1997 / Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell / Nat Med 3:730~737
Al-Hajj M / 2003 / Prospective identification of tumorigenic breast cancer cells / Proc Natl Acad Sci U S A 100:3983~3988
Singh SK / 2004 / Identification of human brain tumour initiating cells / Nature 432:396~401
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