지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objectives : Relapse prevention is a major therapeutic goal in the treatment of schizophrenia. However, many patients experience multiple functional impairments and treatment resistance due to recurrence. This study was designed to investigate the follow-up of patients with using antipsychotic drugs and to compare the total treatment failure rate, withdrawal reasons, and duration period of antipsychotic drugs.
Methods :IThe subjects were 1963 patients who taking antipsychotic drugs under the diagnosis of schizophrenia. We selected 1836 patients using 10 antipsychotic drugs according to frequency of using. The rate of total treatment failure of them was divided into 6-month, 1-year, 2-year, 3-year, and 5-year according to the time of drug withdrawal. We compared the total treatment failure rate at 1 and 3-year between 10 antipsychotic drugs.
Results : The total treatment failure rate of clozapine was lowest compared with the other 9 antipsychotic drugs in all the surveyed periods. When evaluating actual number of subjects, olanzapine, sulpiride, risperidone, aripiprazole, amisulpride, and haloperidol were lower significantly compared with ziprasidone at 1-year in the total treatment failure rate, but there was no significant difference between them except clozapine at 3-year. The results of the analysis based on the number of prescriptions showed that the total treatment failure rate of the atypical antipsychotic drug was lower than that of the typical antipsychotic drug at 1-year, but the difference was decreased over time except quetiapine and ziprasidone.
Conclusion : In conclusion, although there is some controversy about which drug to prescribe to the patient, the clinician needs a proper prescription considering various factors such as efficacy, side effects, price, and formulations of each drug.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Pincus HA / 2010 / From PORT to policy to patient outcomes: crossing the quality chasm / Schizophr Bull 36:109~111
Huang SS / 2013 / Antipsychotic formulation and one-year rehospitalization of schizophrenia patients: a population-based cohort study / Psychiatr Serv 64:1259~1262
Gitlin M / 2001 / Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia / Am J Psychiatry 158:1835~1842
Kane JM / 2009 / A 28-week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia / J Clin Psychiatry 70:572~581
Stroup TS / 2006 / Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic / Am J Psychiatry 163:611~622
Huang SS / 2013 / Antipsychotic formulation and one-year rehospitalization of schizophrenia patients: a population-based cohort study / Psychiatr Serv 64:1259~1262
Gitlin M / 2001 / Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia / Am J Psychiatry 158:1835~1842
Kane JM / 2009 / A 28-week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia / J Clin Psychiatry 70:572~581
Stroup TS / 2006 / Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic / Am J Psychiatry 163:611~622
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