지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 60 - 67 (8page)
- DOI
- 10.16946/kjsr.2021.24.2.60
이용수
초록· 키워드
오류제보하기
Objectives: The optimal duration of maintenance treatment for patients with first-episode schizophrenia (FES) remains unclear.
We examined the first antipsychotic treatment duration and its association with re-initiation of treatment using a nationwide claim database.
Methods: Data from the Health Insurance Review and Assessment Service database in South Korea for 2007?2016 were used.
Linear regression analysis and Cox proportional hazard models were used to evaluate the associations between the duration of the first antipsychotic treatment, time to re-initiation of treatment, and occurrence of treatment re-initiation.
Results: Of 30,143 patients with FES, 80.4% (n=24,231) received <2 years of the first antipsychotic treatment. In patients who discontinued treatment (n=23,030), the rate of treatment re-initiation was 74.2% (n=17,086). As the duration of the first antipsychotic treatment increased, the time to re-initiation of treatment decreased (β=-0.146, p<0.001); however, the rate of treatment reinitiation was relatively constant (hazard ratio=1.001, p<0.001).
Conclusion: Long-term antipsychotic treatment was not significantly associated with the rate of treatment re-initiation but showed a negative association with the time to re-initiation of treatment. Further research is needed to better understand the optimal treatment duration for FES.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
McGrath J / 2008 / Schizophrenia: a concise overview of incidence, prevalence, and mortality / Epidemiol Rev 30:67~76
Robinson D / 1999 / Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder / Arch Gen Psychiatry 56:241~247
Gitlin M / 2001 / Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia / Am J Psychiatry 158:1835~1842
Boonstra G / 2011 / Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients : results from an aborted randomised trial / Int J Psychiatry Clin Pract 15:128~134
Gaebel W / 2011 / Relapse prevention in first-episode schizophrenia : maintenance vs intermittent drug treatment with prodromebased early intervention : results of a randomized controlled trial within the German Research Network on Schizophrenia / J Clin Psychiatry 72:205~218
Robinson D / 1999 / Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder / Arch Gen Psychiatry 56:241~247
Gitlin M / 2001 / Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia / Am J Psychiatry 158:1835~1842
Boonstra G / 2011 / Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients : results from an aborted randomised trial / Int J Psychiatry Clin Pract 15:128~134
Gaebel W / 2011 / Relapse prevention in first-episode schizophrenia : maintenance vs intermittent drug treatment with prodromebased early intervention : results of a randomized controlled trial within the German Research Network on Schizophrenia / J Clin Psychiatry 72:205~218
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