지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 890 - 898 (9page)
- DOI
- 10.4093/dmj.2020.0208
이용수
초록· 키워드
오류제보하기
Background: Fatty liver and/or increased liver enzyme values have been reported to be associated with incident diabetes. We sought to determine whether increased visit-to-visit liver enzyme variability is associated with incident diabetes.Methods: Study participants were recruited from the Korean Genome and Epidemiologic Study (KoGES). A total of 4,151 people aged 40 to 69 years was recruited and tested every 2 years for up to 12 years. Visit-to-visit aspartate aminotransferase (AST) and alanine aminotransferase (ALT) variability was evaluated in first the 6-year period through the use of various variability measurements: standard deviation (SD), average successive variability, coefficient of variation (CV), and variation independent of mean (VIM). Oral glucose tolerance test was performed at every visit.Results: During the 6-year follow?up appointments, 13.0% (538/4,151) of people developed incident diabetes. Visit-to-visit AST variability was associated with an increased risk of diabetes independent of conventional risk factors for diabetes (hazard ratio per 1-SD increment [95% confidence interval]: 1.06 [1.00 to 1.11], 1.12 [1.04 to 1.21], and 1.13 [1.04 to 1.22] for SD, CV, and VIM, respectively; all P<0.05); however, no such associations were observed in the visit-to-visit ALT variability. According to alcohol consumption status, both AST and ALT variability were independent predictors for incident diabetes in subjects with heavy alcohol consumption; however, neither AST nor ALT variability was associated with diabetes risk in subjects who did not drink alcohol heavily.Conclusion: Visit-to-visit liver enzyme variability is an independent predictor of incident diabetes. Such association was more evident in those who consumed significant amounts of alcohol.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
이용호 / 2019 / Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis / Diabetes and Metabolism Journal 43(1):31~45
Targher G / 2018 / Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus / Nat Rev Endocrinol 14:99~114
Valenti L / 2016 / Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes? / Liver Int 36:1563~1579
Mantovani A / 2018 / Nonalcoholic fatty liver disease and risk of incident type 2 diabetes : a metaanalysis / Diabetes Care 41:372~382
Bangalore S / 2018 / Body weight variability and cardiovascular outcomes in patients with type 2 diabetes mellitus / Circ Cardiovasc Qual Outcomes 11:e004724
Targher G / 2018 / Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus / Nat Rev Endocrinol 14:99~114
Valenti L / 2016 / Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes? / Liver Int 36:1563~1579
Mantovani A / 2018 / Nonalcoholic fatty liver disease and risk of incident type 2 diabetes : a metaanalysis / Diabetes Care 41:372~382
Bangalore S / 2018 / Body weight variability and cardiovascular outcomes in patients with type 2 diabetes mellitus / Circ Cardiovasc Qual Outcomes 11:e004724
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