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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제19권 제4호
- 발행연도
- 2018.12
- 수록면
- 92 - 102 (11page)
이용수
초록· 키워드
오류제보하기
The objectives of this study were to find out the plant to enhance immune activity among 42 kinds of foods frequently consumed by the Korean elderly consisting of 5 food groups and 5 wild plants. Each sample was assessed the immunoactive effect by measuring NF-kB/AP1 gene expression, nitric oxide and cytokine production in RAW-Blue™ cell. Soybean sprouts of 47 plants showed the highest NF-κB/AP1 gene expression at the level of 1.13 ± 0.03 (O.D. 650 nm) and Soritae, sweet potato, banana, apple, garlic, crown daisy, cabbage and Ailanthus altissima also had high activity of NF-kB/AP1 gene in RAW-Blue™ cell stimulated by LPS. NO production of Ailanthus altissima was significantly higher than that of other plants and 16 plants of glutinous sorghum, black rice, Seoritae, Heuktae, sweet potato, banana, apple, garlic, mungbean sprouts, spinach, crown daisy, young pumpkin, cabbage, soybean sprouts, Actinidia arguta and Aster scaber were the next best activity. The above results selected 17 out of 47 plant samples. Moreover, soybean sprouts was significantly shown to increase TNF-α (1,509.55 ± 1.38 pg/mL) and IL-1β (54.56 ± 1.08 pg/mL) cytokines in comparison with RAW-Blue cell stimulated by LPS. According to the results of in vitro evaluation, the ethanol extract of soybean sprout increased the production of immune-enhancing cytokines by proliferation of macrophages. In addition, NF-kB transcription factor activity and NO production ability were excellent, and it was selected as a material having excellent immunological activity.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Cannon JG / 2000 / Inflammatory cytokine in non-pathological states / News Physiol Sci 15:298~303
Arunachalam K / 2000 / Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (NH019) / Eur J Clin Nutr 54:263~267
Fearon DT / 1996 / The instructive role of innate immunity in the acquired immune response / Science 272(5258):50~53
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124:783~801
윤영일 / 2014 / LPS로 유도된 RAW 264.7세포에 대한 벼메뚜기(Oxya chinensis sinuosa) 에탄올 추출물의 항염증 효과 / 생명과학회지 24(4):370~376
Arunachalam K / 2000 / Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (NH019) / Eur J Clin Nutr 54:263~267
Fearon DT / 1996 / The instructive role of innate immunity in the acquired immune response / Science 272(5258):50~53
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124:783~801
윤영일 / 2014 / LPS로 유도된 RAW 264.7세포에 대한 벼메뚜기(Oxya chinensis sinuosa) 에탄올 추출물의 항염증 효과 / 생명과학회지 24(4):370~376
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