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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.2
- 수록면
- 15 - 21 (7page)
- DOI
- 10.15188/kjopp.2021.02.35.1.15
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초록· 키워드
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Donggwaja (Benincasae Semen), the seed of Benincasa hispida (Thunb.) Cogn., has been used in Korean traditional medicine to control the body heat and water retention caused by various diseases. Both the symptoms targeted by the herbal medicine in clinic and studies with disease mouse models support the potential anti-inflammatory effect of Donggwaja. However, it is less understood how Donggwaja exerts its possible anti-inflammatory effect. Here, we present evidence that Donggwaja suppresses macrophage inflammatory reactions via expressing tumor necrosis factor a-induced protein 3 (TNFAIP3 or A20) and suppressing NF-kB activity. The ethanol extract of Donggwaja (EED) showed no toxicity when added to RAW 264.7 cells less than 100mg/ml. When treating the cells for 16 h, EED significantly suppressed the nuclear localization of NF-kB, suggesting that EED suppresses NF-kB activity. Concordantly, a semi-quantitative RT-PCR analysis showed that EED decreased the expression of prototypic pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-a, IL(interleukin)-6, and IL-1b. EED induced in RAW 264.7 cells the expression of A20, a ubiquitin modulator that suppresses inflammatory signaling cascades initiated from TLR4 and TNF and IL-1 receptors, while not affecting the induction of Nrf2, an anti-inflammatory factor that could suppress the effect of NF-kB. These results suggest that EED exerts its suppressive effect on inflammation, at least in part, by expressing anti-inflammatory factor A20 and suppressing pro-inflammatory factor NF-kB activity.
목차
서론
재료와 방법
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고찰
References
참고문헌 (24)
참고문헌 신청
Fujiwara N / 2005 / Macrophages in Inflammation / Curr Drug Targets Inflamm Allergy 4(3):281~286
Kimbrell DA / 2001 / The evolution and Genetics of Innate Immunity / Nat Rev Genet 2(4):256~267
Zhang H / 2019 / Catalpol Ameliorates LPS-induced Endometritis by Inhibiting Inflammation and TLR4/NF-kappaB Signaling / J Zhejiang Univ Sci B 20(10):816~827
Israel A / 2010 / The IKK Complex, a Central Regulator of NF-kappaB Activation / Cold Spring Harb Perspect Biol 2(3):a000158
Wertz IE / 2004 / De-ubiquitination and Ubiquitin Ligase Domains of A20 Downregulate NF-kappaB Signalling / Nature 430(7000):694~699
Kimbrell DA / 2001 / The evolution and Genetics of Innate Immunity / Nat Rev Genet 2(4):256~267
Zhang H / 2019 / Catalpol Ameliorates LPS-induced Endometritis by Inhibiting Inflammation and TLR4/NF-kappaB Signaling / J Zhejiang Univ Sci B 20(10):816~827
Israel A / 2010 / The IKK Complex, a Central Regulator of NF-kappaB Activation / Cold Spring Harb Perspect Biol 2(3):a000158
Wertz IE / 2004 / De-ubiquitination and Ubiquitin Ligase Domains of A20 Downregulate NF-kappaB Signalling / Nature 430(7000):694~699
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UCI(KEPA) : I410-ECN-0101-2021-519-001700385