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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 781 - 788 (8page)
- DOI
- http://dx.doi.org/10.14257/AJMAHS.2017.04.27
이용수
초록· 키워드
오류제보하기
The antioxidativepotential of chicoric acid was investigated through heme oxygenase (HO)-1, one of phase II enzymes and exhibits antioxidative activity, induction in RAW 264.7 cells. There were also measured intracellular radical scavenging activity and glutathione (GSH) concentration in chicoric acid treated RAW 264.7 cells. Chicoric acid treatment potently induced HO-1 expression, scavenged reactive oxygen species (ROS) and increased GSH concentration. Transcription factor of phase II enzymes, nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), was investigated and identified in accordance with HO-1 expression. In addition, chicoric acid treatment phosphorylated PI3K/Akt with slight activation of the extrecellularregulated kinase (ERK). Chicoric acid-induced antioxidative potential protected RAW 264.7 cells against oxidative stress-induced cell death. In conclusion, chicoric acid potently accelerated Nrf2-mediated antioxidative potential through the modulation of PI3K/Akt pathway, which would contribute to their promising strategy for a novelanti-oxidative agent.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
V. J. Thannickal / 2000 / Am. J. Physiol. Lung Cell Mol. Physiol 279:L1005~L1028
P. Vitaglione / 2004 / Crit. Rev. Food Sci. Nutr 44:575~586
L. Dalby-Brown / 2005 / J. Agric. Food Chem 53:9413~9423
K. Takuko / 1999 / Nippon Kagaku Kaishi 11:739~750
서영준 / 2006 / Heme Oxygenase-1 as a Potential Therapeutic Target for Hepatoprotection / BMB reports 39(5):479~491
P. Vitaglione / 2004 / Crit. Rev. Food Sci. Nutr 44:575~586
L. Dalby-Brown / 2005 / J. Agric. Food Chem 53:9413~9423
K. Takuko / 1999 / Nippon Kagaku Kaishi 11:739~750
서영준 / 2006 / Heme Oxygenase-1 as a Potential Therapeutic Target for Hepatoprotection / BMB reports 39(5):479~491
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