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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 103 - 108 (6page)
- DOI
- 10.18700/jnc.210028
이용수
초록· 키워드
오류제보하기
Background: Neuropsychiatric systemic lupus erythematosus (NPSLE) has a diverse and broad spectrum of severity and prognosis, with some devastating manifestations. However, its diagnosis and treatment remain unclear and controversial. Case Report: A 19-year-old woman with SLE presented with fever, headache, quadriparesis, and tremor. Brain magnetic resonance imaging (MRI) showed sulcal enhancement in the cortical sulcus, and intravenous methylprednisolone (500 mg/day) and immunoglobulin (2 g/kg for 5 days) were started under the suspicion of aseptic lupus meningitis. However, the patient’s neurologic symptoms worsened; brain MRI showed a newly developed brain parenchymal lesion, suggesting lupus cerebritis and posterior reversible encephalopathy syndrome. Two cycles of rituximab (850 mg/day, 1-week interval) were administered for the treatment of refractory NPSLE. Her neurologic symptoms gradually improved after the second cycle, and she was discharged with minimal neurologic symptoms. Conclusion: Rituximab may be a therapeutic option for refractory lupus cerebritis. Further research is needed to accurately determine its efficacy.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Govoni M / 2016 / The diagnosis and clinical management of the neuropsychiatric manifestations of lupus / J Autoimmun 74:41~72
1999 / The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes / Arthritis Rheum 42:599~608
Schwartz N / 2019 / Neuropsychiatric lupus : new mechanistic insights and future treatment directions / Nat Rev Rheumatol 15:137~152
Carrión-Barberà I / 2021 / Neuropsychiatric involvement in systemic lupus erythematosus : a review / Autoimmun Rev 20:102780
Muhammad O / 2021 / Systemic lupus erythematosus with multi-organ involvement in a young female : lymphadenopathy, lupus cerebritis, lupus nephritis, and cardiac manifestations / Cureus 13:e15517
1999 / The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes / Arthritis Rheum 42:599~608
Schwartz N / 2019 / Neuropsychiatric lupus : new mechanistic insights and future treatment directions / Nat Rev Rheumatol 15:137~152
Carrión-Barberà I / 2021 / Neuropsychiatric involvement in systemic lupus erythematosus : a review / Autoimmun Rev 20:102780
Muhammad O / 2021 / Systemic lupus erythematosus with multi-organ involvement in a young female : lymphadenopathy, lupus cerebritis, lupus nephritis, and cardiac manifestations / Cureus 13:e15517
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