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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 77 - 83 (7page)
- DOI
- 10.14449/jbd.2021.9.2.77
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Purpose: Breast conserving surgery (BCS) is generally not considered for breast cancer because of concerns about the poor prognosis of triple negative breast cancer (TNBC). We assessed the outcomes of BCS and mastectomy for patients with stage II-IIIA TNBC. Methods: The data of 172 breast cancer patients diagnosed with stage II-IIIA TNBC who underwent treatment at Pusan National University Hospital and Pusan National University Yangsan Hospital from 2010 to 2014 were retrospectively analyzed. The patients were divided into the following two groups: patients who underwent BCS (n=101) and those who underwent mastectomy (n=71). The Cox regression model was used to examine the outcomes of both treatments. The median follow-up period was 71 months in the BCS group, and 67 months in the mastectomy group. Results: The median age of the 172 patients was 51 years (range, 22-82 years). In the BCS group, radiation therapy and chemotherapy (p<0.001 and p=0.007, respectively) were performed more frequently. The BCS group had more patients with a high Ki-67 index (p=0.006), while the mastectomy group included more patients with a higher pathologic T (pT) stage (p=0.005). The 5-year loco-regional recurrence-free, disease-free, and overall survival rates of the BCS group versus the mastectomy group were 93.8% versus 95.3%, 89.8% versus 90.7%, and 90.8% versus 86.3%, respectively, but the differences were not statistically significant. Lymphovascular invasion was a risk factor for disease-free survival and advanced stage was an important risk factor for overall survival. Conclusion: In stage II-IIIA TNBC, BCS was not inferior to mastectomy in locoregional recurrence rates, disease-free survival rates, or overall survival rates.
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참고문헌 (24)
참고문헌 신청
Fitzal F / 2011 / Oncologic safety of breast conserving surgery after tumour downsizing by neoadjuvant therapy : a retrospective single centre cohort study / Breast Cancer Res Treat 127:121~128
Golshan M / 2015 / Impact of neoadjuvant chemotherapy in stage II-III triple negative breast cancer on eligibility for breast-conserving surgery and breast conservation rates : surgical results from CALGB 40603(Alliance) / Ann Surg 262:434~439
Golshan M / 2016 / Impact of neoadjuvant therapy on eligibility for and frequency of breast conservation in stage II-III HER2-positive breast cancer : surgical results of CALGB 40601(Alliance) / Breast Cancer Res Treat 160:297~304
모혜진 / 2017 / Actual Conversion Rate from Total Mastectomy to Breast Conservation after Neoadjuvant Chemotherapy for Stages II–III Breast Cancer Patients / Journal of Breast Disease 5(2):51~56
Chintamani / 2011 / The correlation of anxiety and depression levels with response to neoadjuvant chemotherapy in patients with breast cancer / JRSM Short Rep 2:1~5
Golshan M / 2015 / Impact of neoadjuvant chemotherapy in stage II-III triple negative breast cancer on eligibility for breast-conserving surgery and breast conservation rates : surgical results from CALGB 40603(Alliance) / Ann Surg 262:434~439
Golshan M / 2016 / Impact of neoadjuvant therapy on eligibility for and frequency of breast conservation in stage II-III HER2-positive breast cancer : surgical results of CALGB 40601(Alliance) / Breast Cancer Res Treat 160:297~304
모혜진 / 2017 / Actual Conversion Rate from Total Mastectomy to Breast Conservation after Neoadjuvant Chemotherapy for Stages II–III Breast Cancer Patients / Journal of Breast Disease 5(2):51~56
Chintamani / 2011 / The correlation of anxiety and depression levels with response to neoadjuvant chemotherapy in patients with breast cancer / JRSM Short Rep 2:1~5
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