지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 608 - 617 (10page)
- DOI
- 10.14245/ns.2142544.272
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초록· 키워드
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Objective: This study aimed to identify the sagittal parameters associated with health-related quality of life and genetic variations that increase the risk of adult spinal deformity (ASD) onset in the older population.
Methods: We recruited 120 participants who had a sagittal vertical axis >50 mm in a sagittal imbalance study. Sagittal radiographic parameters, cross-sectional area, and intramuscular fatty infiltration using the Goutallier classification in the paraspinal lumbar muscles were evaluated. Functional scales included the self-reported Oswestry Disability Index (ODI), 36-item Short Form Health Survey (SF-36), and visual analogue scales (VAS) for back and leg pain. We performed whole-exome sequencing and an exome-wide association study using the 100 control subjects and 63 individuals with severe phenotypes of sagittal imbalance.
Results: Pelvic incidence minus lumbar lordosis (PI?LL) mismatch was negatively associated with the SF-36 and positively correlated with ODI and VAS for back and leg pain. PI?LL was related to the quality and size of the paraspinal muscles, especially the multifidus muscle. We identified common individual variants that reached exome-wide significance using single-variant analysis. The most significant single-nucleotide polymorphism was rs78773460, situated in an exon of the SVIL gene (odds ratio, 9.61; p=1.15×10-9).
Conclusion: Older age, higher body mass index, and a more significant PI?LL mismatch were associated with unfavorable results on functional scales. We found a genetic variation in the SVIL gene, which has been associated with the integrity of the cytoskeleton and the development of skeletal muscles, in severe ASD phenotypes. Our results help to elucidate the pathogenesis of ASD.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Asai Y / 2017 / Sagittal spino-pelvic alignment in adults: the Wakayama Spine Study / PLoS One 12:e0178697
Ailon T / 2015 / Degenerative spinal deformity / Neurosurgery 77(Suppl 4):S75~S91
Roussouly P / 2006 / Sagittal alignment of the spine and pelvis in the presence of L5-s1 isthmic lysis and low-grade spondylolisthesis / Spine 31:2484~2490
Schwab FJ / 2013 / Radiographical spinopelvic parameters and disability in the setting of adult spinal deformity: a prospective multicenter analysis / Spine 38:E803~E812
Aoki Y / 2015 / Influence of pelvic incidence-lumbar lordosis mismatch on surgical outcomes of short-segment transforaminal lumbar interbody fusion / BMC Musculoskelet Disord 16:213
Ailon T / 2015 / Degenerative spinal deformity / Neurosurgery 77(Suppl 4):S75~S91
Roussouly P / 2006 / Sagittal alignment of the spine and pelvis in the presence of L5-s1 isthmic lysis and low-grade spondylolisthesis / Spine 31:2484~2490
Schwab FJ / 2013 / Radiographical spinopelvic parameters and disability in the setting of adult spinal deformity: a prospective multicenter analysis / Spine 38:E803~E812
Aoki Y / 2015 / Influence of pelvic incidence-lumbar lordosis mismatch on surgical outcomes of short-segment transforaminal lumbar interbody fusion / BMC Musculoskelet Disord 16:213
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