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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 61 - 65 (5page)
- DOI
- https://doi.org/10.13041/jpvm.2018.42.2.61
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초록· 키워드
오류제보하기
Doxorubicin has been used to treating cancers, including breast cancer, bladder cancer, and acute lymphocytic leukemia, however, few studies have investigated its anti-inflammatory activity. In this study, we used mouse spleen cells treated with lipopolysaccharide (LPS), a representative inflammatory agent to investigate the effects of doxorubicin. Specially, we investigated the effects of doxorubicin on metabolic activity, cell size, cell death, and cytokine production of LPS-treated spleen cells. Doxorubicin significantly decreased the metabolic activity, even when applied at relatively low concentrations (1.6-8 ng/mL). To investigate the potential mechanism, we measured the mitochondrial membrane potential (MMP) of the LPS-treated spleen cells using Rhodamine 123. Doxorubicin decreased MMP and cell size, and induced cell death. Furthermore, doxorubicin suppressed the production of tumor necrosis factor (TNF)-alpha, a representative cytokine, in LPS-treated spleen cells. Taken together, doxorubicin decreased metabolic activity and the production of inflammatory cytokines, while increasing the death of LPS-induced hyperactivated spleen cells. This results will enable broader application of doxorubicin, as an anti-inflammatory agent, in clinical and research fields.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
안상은 / 2017 / Anti-inflammatory activity of Rhus chinensis extract on bone marrow cells via decrease of metabolic activity and modulation of the production of inflammation-related cytokines / 예방수의학회지 41(1):20~25
Chatterjee K / 2010 / Doxorubicin Cardiomyopathy / Cardiology 115:155~162
Chen LB / 1988 / Mitochondrial membrane potential in living cells / Annu Rev Cell Biol 4:155~181
Yong Han / 2015 / Protective effects of fucoidan on the cell death of spleen cells induced by taxol / 예방수의학회지 39(4):185~188
Huang M / 2007 / Mitochondrial inner membrane electrophysiology assessed by rhodamine-123 transport and fluorescence / Ann Biomed Eng 35:1276~1285
Chatterjee K / 2010 / Doxorubicin Cardiomyopathy / Cardiology 115:155~162
Chen LB / 1988 / Mitochondrial membrane potential in living cells / Annu Rev Cell Biol 4:155~181
Yong Han / 2015 / Protective effects of fucoidan on the cell death of spleen cells induced by taxol / 예방수의학회지 39(4):185~188
Huang M / 2007 / Mitochondrial inner membrane electrophysiology assessed by rhodamine-123 transport and fluorescence / Ann Biomed Eng 35:1276~1285
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