Protective effects and mechanism of coenzyme Q10 and vitamin C on doxorubicin-induced gastric mucosal injury and effects of intestinal flora

Xiaomeng Zhao; Xueke Feng; Nan Ye; Panpan Wei; Zhanwei Zhang; Wenyu Lu

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자료유형: 학술저널

저자정보: Xiaomeng Zhao (School of Chemical Engineering and Technology Tianjin University Tianjin 300072 PR China) Xueke Feng (School of Chemical Engineering and Technology Tianjin University Tianjin 300072 PR China) Nan Ye (School of Chemical Engineering and Technology Tianjin University Tianjin 300072 PR China) Panpan Wei (School of Chemical Engineering and Technology Tianjin University Tianjin 300072 PR China) Zhanwei Zhang (School of Chemical Engineering and Technology Tianjin University Tianjin 300072 PR China) Wenyu Lu (School of Chemical Engineering and Technology Tianjin University Tianjin 300072 PR ChinaKey Laborat)

저널정보: 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제4호

발행연도: 2021.1

수록면: 261 - 272 (12page)

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Doxorubicin (Dox) is widely used to the treatment of cancer, however, it could cause damage to gastric mucosa. To investigate the protective effects and related mechanisms of coenzyme Q10 (CoQ10) and vitamin C (VC) on Dox-induced gastric mucosal injury, we presented the survey of the 4 groups of the rats with different conditions. The results showed Dox treatment significantly induced GES-1 apoptosis, but preconditioning in GES-1 cells with VC or CoQ10 significantly inhibited the Dox-induced decrease and other harm effects, including the expression and of I?K?, I?B?, NF-?B/p65 and tumor necrosis factor (TNF-?) in GES-1 cells. Moreover, high-throughput sequencing results showed Dox treatment increased the number of harmful gut microbes, and CoQ10 and VC treatment inhibited this effect. CoQ10 and VC treatment inhibits Dox-induced gastric mucosal injury by inhibiting the activation of the IkKB/I?B?/NF-?B/p65/TNF-? pathway, promoting anti-inflammatory effects of gastric tissue and regulating the composition of the intestinal flora

#Coenzyme Q10 #Doxorubicin #NF-kB pathway #Vitamin C

참고문헌 (29)

참고문헌 신청

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