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논문 기본 정보

자료유형
학술저널
저자정보
Terence Kee (SingHealth Duke-National University of Singapore Transplant Centre) Jong Cheol Jeong (Seoul National University) Harun Ur Rashid (Kidney Foundation Hospital and Research Institute) Nura Afza Salma Begum (Kidney Foundation Hospital and Research Institute) Mel-Hatra Arakama (National Kidney and Transplant Institute) Romina Danguilan (National Kidney and Transplant Institute) Lkhaahuu Od-Erdene (First Central Hospital) Rosnawati Yahya (Kuala Lumpur Hospital) 김예림 (Department of Internal Medicine Keimyung University School of Medicine Kidney Institute Daegu Ko) Hersharan Kaur Sran (National University Hospital Singapore) Becky Ma (Queen Mary Hospital) Maggie Ma (Queen Mary Hospital) Devinder Singh Rana (Sir Ganga Ram Hospital) Curie Ahn (Department of Internal Medicine Seoul National University College of Medicine) Ghazali Ahmad (National Heart Institute)
저널정보
대한이식학회 Clinical Transplantation and Research Korean Journal of Transplantation Vol.35 No.4
발행연도
2021.12
수록면
218 - 229 (12page)
DOI
10.4285/kjt.21.0024

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Background: Asia is the global epicenter of the coronavirus disease 2019 (COVID-19) pandemic; however, COVID-19?related mortality in Asia remains lower than in other parts of the world. It is uncertain whether the mortality of COVID-19-infected kidney transplant recipients (KTXs) from Asia follows the lower mortality trends of the younger Asian population. Methods: Specific transplant centers from countries in the Asian Society of Transplantation were invited to participate in a study to examine the epidemiology, clinical features, natural history, and outcomes of COVID-19 infections in KTXs. Data were analyzed and compared with those of large cohort studies from other countries. Results: The study population was 87 KTXs from nine hospitals in seven Asian countries. Within the study population, 9% were aged 60 years and older, and 79% had at least one comorbidity. The majority of patients (69%) presented with mild-to-moderate COVID-19 severity. Disease progression was more frequently encountered among those with moderate or severe infection (23%) and non-survivors (55%). The mortality rate was 23% (n=20) and differed according to the level of care: 12% (n=1/8), 15% (n=10/67), and 100% (n=9/9) of patients managed as outpatients, in the general ward, and in the intensive care unit, respectively. Disease severity at the time of presentation was an independent predictor of mortality. Compared with the mortality rates in other studies worldwide, mortality rates in the current study were comparable. Conclusions: Mortality in Asian KTXs who were infected with COVID-19 remains high and could be related to comorbidity burden and the constraints of the general healthcare system when the COVID-19 caseload is high.
#Kidney transplantation #COVID-19 #Asia #Registry

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참고문헌 (24)

참고문헌 신청
Terence Kee / 2020 / Transplantation in Asia during the coronavirus disease-19 (COVID-19) pandemic: briefs from member countries of the Asian Society of Transplantation / Korean Journal of Transplantation 34(2):71~77 dbpia Kremer D / 2021 / A systematic review and meta-analysis of COVID-19 in kidney transplant recipients : lessons to be learned / Am J Transplant 21:3936~3945 google schola Azzi Y / 2021 / COVID-19 and solid organ transplantation : a review article / Transplantation 105:37~55 google schola Jeong JC / 2020 / Development of the Asian transplant registry under the Asian Society of Transplantation / Transplant Proc 52:1634~1638 google schola Kute VB / 2021 / Clinical profile and outcome of COVID-19 in 250 kidney transplant recipients : a multicenter cohort study from India / Transplantation 105:851~860 google schola

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