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논문 기본 정보

자료유형
학술저널
저자정보
Kanika Sehgal (Division of Gastroenterology and Hepatology Mayo Clinic) Sahil Khanna (Division of Gastroenterology and Hepatology Mayo Clinic)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.19 No.4
발행연도
2021.10
수록면
360 - 364 (5page)
DOI
10.5217/ir.2020.00116

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초록· 키워드

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Immune checkpoint inhibitor therapies such as ipilimumab, are increasingly being used as a treatment option for a variety of cancers, including metastatic melanoma and have demonstrated effectively a prolonged survival. These agents have an immunological mode of action that predisposes patients to a number of immune-related adverse events, colitis being one of the most commonly encountered complications. The pathogenesis for the development of colitis is unclear, and there is a growing consensus that the ecosystem of the gastrointestinal microbiota plays a significant role. Based on this suspected connection, studies are being carried out to explore the changes in the microbiota in patients on these medications who develop colitis. Conceivably, the modulation of the gut microbiota could offer a therapeutic benefit. Fecal microbiota transplantation is one therapeutic option that is currently being investigated, though there are still more data needed to evaluate its efficacy. In this review, we recapitulate the mechanisms of action of immune checkpoint inhibitors, their adverse events, with a focus on colitis and the role gut microbiota are suspected to play, and finally discuss the microbiota modulation therapies being investigated.

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