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- 대한수의학회 Korean Journal of Veterinary Research(대한수의학회지) Korean Journal of Veterinary Research(구 대한수의학회지) 제55권 제1호
- 발행연도
- 2015.3
- 수록면
- 57 - 60 (4page)
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To investigate kinetics of free <sup>177</sup>Lu and <sup>177</sup>Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of 5 μCi/ mouse or 15 mg/kg body weight, respectively. Free <sup>177</sup>Lu radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. <sup>177</sup>Lu-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p<0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.
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