지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 280 - 287 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: This study was performed to examine the treatment of erectile dysfunction by use of superparamagnetic iron oxide nanoparticles-labeled human mesenchymal stem cells (SPION-MSCs) transplanted into the cavernous nerve injured cavernosa of rats as monitored by molecular magnetic resonance imaging (MRI).
Materials and Methods: Eight-week-old male Sprague-Dawley rats were divided into three groups of 10 rats each: group 1, sham operation; group 2, cavernous nerve injury; group 3, SPION-MSC treatment after cavernous nerve injury. Immediately after the cavernous nerve injury in group 3, SPION-MSCs were injected into the cavernous nerve injured cavernosa. Serial T2-weighted MRI was done immediately after injection and at 2 and 4 weeks. Erectile response was assessed by cavernous nerve stimulation at 2 and 4 weeks.
Results: Prussian blue staining of SPION-MSCs revealed abundant uptake of SPION in the cytoplasm. After injection of 1×106 SPION-MSCs into the cavernosa of rats, T2-weighted MRI showed a clear hypointense signal induced by the injection. The presence of SPION in the corpora cavernosa was confirmed with Prussian blue staining. At 2 and 4 weeks, rats with cavernous nerve injury had significantly lower erectile function than did rats without cavernous nerve injury (p<0.05). The group transplanted with SPION-MSCs showed higher erectile function than did the group without SPION-MSCs (p<0.05). The presence of SPION-MSCs for up to 4 weeks was confirmed by MRI imaging and Prussian blue staining in the corpus cavernosa.
Conclusions: Transplanted SPION-MSCs existed for up to 4 weeks in the cavernous nerve injured cavernosa of rats. Erectile dysfunction recovered and could be monitored by MRI.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Quinlan DM / 1991 / Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles / J Urol 145:998~1002
Hatzimouratidis K / 2009 / Phosphodiesterase type 5 inhibitors in postprostatectomy erectile dysfunction: a critical analysis of the basic science rationale and clinical application / Eur Urol 55:334~347
Montorsi F / 2008 / Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nervesparing radical prostatectomy / Eur Urol 54:924~931
Fall PA / 2009 / Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction / Eur Urol 56:716~725
Kendirci M / 2010 / Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury / J Urol 184:1560~1566
Hatzimouratidis K / 2009 / Phosphodiesterase type 5 inhibitors in postprostatectomy erectile dysfunction: a critical analysis of the basic science rationale and clinical application / Eur Urol 55:334~347
Montorsi F / 2008 / Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nervesparing radical prostatectomy / Eur Urol 54:924~931
Fall PA / 2009 / Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction / Eur Urol 56:716~725
Kendirci M / 2010 / Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury / J Urol 184:1560~1566
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Dose- and sex-dependent effects on umbilical cord-derived mesenchymal stem cell efficacy in regeneration of a full- thickness tendon defect in a rat model
대한견주관절의학회지
2025 .03
-
Effects of Mesenchymal Stem Cells Treatment on Radiation-Induced Proctitis in Rats
Yonsei Medical Journal
2023 .03
-
Functional and quantitative MR imaging of microvasculature with contrast agent
한국실험동물학회 학술발표대회 논문집
2015 .02
-
The advantages and limitations of mesenchymal stem cells in clinical application for treating human diseases
Osteoporosis and Sarcopenia
2018 .01
-
Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)
생체재료학회지
2023 .03
-
The Therapeutic Effect of Human Embryonic Stem Cell-Derived Multipotent Mesenchymal Stem Cells on Chemical-Induced Cystitis in Rats
International Neurourology Journal
2018 .01
-
클러스터 초상자성체 산화철 나노입자를 이용한 색채학적 해석 기반 당 측정
의공학회지
2020 .01
-
Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice
Korean Journal of Veterinary Research(대한수의학회지)
2015 .03
-
Biodistribution of poly clustered superparamagnetic iron oxide nanoparticle labeled mesenchymal stem cells in aminoglycoside induced ototoxic mouse model
Biomedical Engineering Letters (BMEL)
2021 .01
-
Temporal Volume Change of Cavernous Sinus Cavernous Hemangiomas after Gamma Knife Surgery
Yonsei Medical Journal
2020 .01
-
A Case of Widespread Cavernous Malformations of the Central Nervous System Associated with Acute Neurologic Deficit
Investigative Magnetic Resonance Imaging
2017 .01
-
The effect of mesenchymal stem cell use on intraabdominal adhesions in a rat model
Annals of Surgical Treatment and Research
2018 .02
-
Establishment of bovine tongue epithelium-derived mesenchymal stem cells
예방수의학회지
2017 .09
-
Isolation and characterization of deer-derived mesenchymal stem cells
예방수의학회지
2019 .01
-
Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury
Journal of Veterinary Science
2017 .09
-
Comparative characteristic study from bone marrow-derived mesenchymal stem cells
Journal of Veterinary Science
2021 .11
-
Comparison of characteristics of mesenchymal stem cells from bovine
예방수의학회지
2021 .01
-
Regulatory Dendritic Cells Induced by Mesenchymal Stem Cells Ameliorate Dextran Sodium Sulfate-Induced Chronic Colitis in Mice
Gut and Liver
2018 .01
-
Canine adipose tissue-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating T cells in rats
Journal of Veterinary Science
2016 .12
-
Anti-inflammatory effects of equine adipose-derived mesenchymal stem cells for bone fracture in thoroughbred racehorses
예방수의학회지
2015 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0