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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 343 - 348 (6page)
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초록· 키워드
오류제보하기
Fiber type-specific programs controlled by the transcription factor MEF2 dictate muscle functionality. Here, we show that HDAC4, a potent MEF2 inhibitor, is predominantly localized to the nuclei in fast/glycolytic fibers in contrast to the sarcoplasm in slow/oxidative fibers. The cytoplasmic localization is associated with HDAC4 hyper-phosphorylation in slow/oxidative- fibers. Genetic reprogramming of fast/glycolytic fibers to oxidative fibers by active CaMKII or calcineurin leads to increased HDAC4 phosphorylation, HDAC4 nuclear export, and an increase in markers associated with oxidative fibers. Indeed, HDAC4 represses the MEF2-dependent, PGC- 1α-mediated oxidative metabolic gene program. Thus differential phosphorylation and localization of HDAC4 contributes to establishing fiber type-specific transcriptional programs.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Akimoto, T. / 2004 / Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice / Am. J. Physiol. Cell Physiol 287:1311~1319
Akimoto, T. / 2004 / Real-time imaging of peroxisome proliferator-activated receptor-gamma coactivator-1alpha promoter activity in skeletal muscles of living mice / Am. J. Physiol. Cell Physiol 287:790~796
Backs, J. / 2006 / CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy / J. Clin. Invest 116:1853~1864
Bassel-Duby, R. / 2006 / Signaling pathways in skeletal muscle remodeling / Ann. Rev. Biochem 75:19~37
Black, B. L. / 1998 / Transcriptional control of muscle development by myocyte enhancer factor-2(MEF2)proteins / Annu. Rev. Cell Dev. Biol 14:167~196
Akimoto, T. / 2004 / Real-time imaging of peroxisome proliferator-activated receptor-gamma coactivator-1alpha promoter activity in skeletal muscles of living mice / Am. J. Physiol. Cell Physiol 287:790~796
Backs, J. / 2006 / CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy / J. Clin. Invest 116:1853~1864
Bassel-Duby, R. / 2006 / Signaling pathways in skeletal muscle remodeling / Ann. Rev. Biochem 75:19~37
Black, B. L. / 1998 / Transcriptional control of muscle development by myocyte enhancer factor-2(MEF2)proteins / Annu. Rev. Cell Dev. Biol 14:167~196
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