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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 580 - 586 (7page)
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초록· 키워드
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While increasing evidence indicates the important function of histone methylation during development, how this process influences cardiac development in vertebrates has not been explored. Here, we elucidate the functions of two histone H3 lysine 4 (H3K4) methylation enzymes, SMYD3 and SETD7, during zebrafish heart morphogenesis using gene expression profiling by whole mount in situ hybridization and antisense morpholino oligonucleotide (MO)- based gene knockdown. We find both smyd3 and setd7 are highly expressed within developing zebrafish heart and knock-down of these genes led to severe defects in cardiac morphogenesis without altering the expressions pattern of heart markers, including cmlc2, vmhc, and amhc.
Furthermore, double knock-down by coinjection of smyd3 and setd7 MOs caused the synergistic defects in heart development. As similar to knock-down effect, overexpression of these genes also caused the heart morphogenesis defect in zebrafish. These results indicate that histone modifying enzymes, SMYD3 and SETD7, appear to function synergistically during heart development and their proper functioning is essential for normal heart morphogenesis during development.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Arrowsmith, C. H. / 2012 / Epigenetic protein families : a new frontier for drug discovery / Nat. Rev. Drug Discov 11:384~400
Barnett, P. / 2012 / Localized and temporal gene regulation in heart development / Curr. Top. Dev. Biol 100:171~201
Bhaumik, S. R. / 2007 / Covalent modifications of histones during development and disease pathogenesis / Nat. Struct. Mol. Biol 14:1008~1016
Black, J. C. / 2012 / Histone lysine methylation dynamics : establishment, regulation, and biological impact / Mol. Cell 48:491~507
Campaner, S. / 2011 / The methyltransferase Set7/9(Setd7)is dispensable for the p53-mediated DNA damage response in vivo / Mol. Cell 43:681~688
Barnett, P. / 2012 / Localized and temporal gene regulation in heart development / Curr. Top. Dev. Biol 100:171~201
Bhaumik, S. R. / 2007 / Covalent modifications of histones during development and disease pathogenesis / Nat. Struct. Mol. Biol 14:1008~1016
Black, J. C. / 2012 / Histone lysine methylation dynamics : establishment, regulation, and biological impact / Mol. Cell 48:491~507
Campaner, S. / 2011 / The methyltransferase Set7/9(Setd7)is dispensable for the p53-mediated DNA damage response in vivo / Mol. Cell 43:681~688
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