지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 806 - 813 (8page)
- DOI
- 10.14348/molcells.2015.0117
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초록· 키워드
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Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the glucocerebrosidase gene (GBA), which encodes the lysosomal enzyme glucosylceramidase (GCase). Deficiency in GCase leads to characteristic visceral pathology and lethal neurological manifestations in some patients. Investigations into neurogenesis have suggested that neurodegenerative disorders, such as GD, could be overcome or at least ameliorated by the generation of new neurons. Bone marrowderived mesenchymal stem cells (BM-MSCs) are potential candidates for use in the treatment of neurodegenerative disorders because of their ability to promote neurogenesis.
Our objective was to examine the mechanism of neurogenesis by BM-MSCs in GD. We found that neural stem cells (NSCs) derived from a neuronopathic GD model exhibited decreased ability for self-renewal and neuronal differentiation.
Co-culture of GBA-deficient NSCs with BM-MSCs resulted in an enhanced capacity for self-renewal, and an increased ability for differentiation into neurons or oligodendrocytes.
Enhanced proliferation and neuronal differentiation of GBA-deficient NSCs was associated with elevated release of macrophage colony-stimulating factor (M-CSF) from BM-MSCs. Our findings suggest that soluble M-CSF derived from BM-MSCs can modulate GBA-deficient NSCs, resulting in their improved proliferation and neuronal differentiation.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Adachi, M. / 1967 / Fine structure of central nervous system in early infantile Gaucher's disease / Arch. Pathol 83:513~526
Bae, J. S. / 2007 / Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration / Stem Cells 25:1307~1316
Bajetto, A. / 2001 / Chemokines and their receptors in the central nervous system / Front Neuroendocrinol 22:147~184
Beutler, E. / 2001 / The metabolic and molecular bases of inherited diseases / McGraw-Hill :3635~3668
Block, G. J. / 2009 / Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1 / Stem Cells 27:670~681
Bae, J. S. / 2007 / Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration / Stem Cells 25:1307~1316
Bajetto, A. / 2001 / Chemokines and their receptors in the central nervous system / Front Neuroendocrinol 22:147~184
Beutler, E. / 2001 / The metabolic and molecular bases of inherited diseases / McGraw-Hill :3635~3668
Block, G. J. / 2009 / Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1 / Stem Cells 27:670~681
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