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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 728 - 733 (6page)
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초록· 키워드
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Mesenchymal stem cells (MSCs) effectively reduce airway inflammation and regenerate the alveolus in cigarette- and elastase-induced chronic obstructive pulmonary disease (COPD) animal models. The effects of stem cells are thought to be paracrine and immune-modulatory because very few stem cells remain in the lung one day after their systemic injection, which has been demonstrated previously. In this report, we analyzed the gene expression profiles to compare mouse lungs with chronic exposure to cigarette smoke with non-exposed lungs. Gene expression profiling was also conducted in a mouse lung tissue with chronic exposure to cigarette smoke following the systemic injection of human cord blood-derived mesenchymal stem cells (hCB-MSCs). Globally, 834 genes were differentially expressed after systemic injection of hCB-MSCs. Seven and 21 genes, respectively, were up-and down-regulated on days 1, 4, and 14 after HCB-MSC injection. The Hbb and Hba, genes with oxygen transport and anti-oxidant functions, were increased on days 1 and 14. A serine protease inhibitor was also increased at a similar time point after injection of hCB-MSCs. Gene Ontology analysis indicated that the levels of genes related to immune responses, metabolic processes, and blood vessel development were altered, indicating host responses after hCB-MSC injection. These gene expression changes suggest that MSCs induce a regeneration mechanism against COPD induced by cigarette smoke. These analyses provide basic data for understanding the regeneration mechanisms promoted by hCB-MSCs in cigarette smoke-induced COPD.
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참고문헌 (30)
참고문헌 신청
Aaron, S. D. / 2007 / Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease : a randomized trial / Ann. Intern. Med 146:545~555
Ahmad, M. K. / 2016 / Protective effect of taurine against potassium bromate-induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood / Environ. Toxicol 31:304~313
Banks, M. F. / 2005 / Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts / J. Appl. Physiol 98(1985):732~738
Benarafa, C. / 2007 / The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection / J. Exp. Med 204:1901~1909
Calverley, P. M. / 2007 / Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease / N. Engl. J. Med 356:775~789
Ahmad, M. K. / 2016 / Protective effect of taurine against potassium bromate-induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood / Environ. Toxicol 31:304~313
Banks, M. F. / 2005 / Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts / J. Appl. Physiol 98(1985):732~738
Benarafa, C. / 2007 / The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection / J. Exp. Med 204:1901~1909
Calverley, P. M. / 2007 / Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease / N. Engl. J. Med 356:775~789
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