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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 1,044 - 1,053 (10page)
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This study first investigated the effects of corn gluten hydrolysate (CGH) (1.5 g/day) administration for 7 days on appetite-responsive genes in lean Sprague-Dawley (SD) rats. In a second set of experiments, the metabolic changes occurring at multiple time points over 8 weeks in response to CGH (35.33% wt/wt) were observed in high-fat (HF, 60% of energy as fat) diet-fed SD rats. In lean rats, the hypothalamus neuropeptide-Y and proopiomelanocortin mRNA levels of the CGH group were significantly changed in response to CGH administration.
In the second part of the study, CGH treatment was found to reduce body weight and perirenal and epididymal fat weight. CGH also prevented an increase in food intake at 2 weeks and lowered plasma leptin and insulin levels in comparison with the HF group. This reduction in the plasma and hepatic lipid levels was followed by improved insulin resistance, and the beneficial metabolic effects of CGH were also partly related to increases in plasma adiponectin levels. The Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR), an index of insulin resistance, was markedly improved in the HFCGH group compared with the HF group at 6 weeks. According to the microarray results, adipose tissue mRNA expression related to G-protein coupled receptor protein signaling pathway and sensory perception was significantly improved after 8 weeks of CGH administration. In conclusion, the present findings suggest that dietary CGH may be effective for improving hyperglycemia, dyslipidemia and insulin resistance in diet-induced obese rats as well as appetite control in lean rats.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Adam, C. / 2014 / Dose-dependent effects of a soluble dietary fibre(pectin)on food intake, adiposity, gut hypertrophy and gut satiety hormone secretion in rats / PLoS One 10:e0115438~e0115438
Aoyama, T. / 2000 / Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice(yellow KK) / Nutrition 16:349~354
Ashburner, M. / 2000 / Gene ontology : tool for the unification of biology / The Gene Ontology Consortium. Nat. Genet 25:25~29
Beck, B. / 1990 / Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status / Brain Res 528:245~249
Bligh, E. G. / 1959 / A rapid method of total lipid extraction and purification / Can. J. Biochem. Physiol 37:911~917
Aoyama, T. / 2000 / Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice(yellow KK) / Nutrition 16:349~354
Ashburner, M. / 2000 / Gene ontology : tool for the unification of biology / The Gene Ontology Consortium. Nat. Genet 25:25~29
Beck, B. / 1990 / Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status / Brain Res 528:245~249
Bligh, E. G. / 1959 / A rapid method of total lipid extraction and purification / Can. J. Biochem. Physiol 37:911~917
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