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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 352 - 357 (6page)
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Vertebrate neurogenesis requires inhibition of endoge-nous bone morphogenetic protein (BMP) signals in the ectoderm. Blocking of BMPs in animal cap explants caus-es the formation of anterior neural tissues as a default fate. To identify genes involved in the anterior neural specification, we analyzed gene expression profiles using a Xenopus Affymetrix Gene Chip after BMP-4 inhibition in animal cap explants. We found that the xCyp26c gene, encoding a retinoic acid (RA) degradation enzyme, was upregulated following inhibition of BMP signaling in early neuroectodermal cells. Whole-mount in situ hybridization analysis showed that xCyp26c expression started in the anterior region during the early neurula stage. Overexpression of xCyp26c weakly induced neural genes in animal cap explants. xCyp26c abolished the expression of all trans-/cis-RA-induced posterior genes, but not basic FGF-induced posterior genes. Depletion of xCyp26c by morpholino-oligonucleotides suppressed the normal formation of the axis and head, indicating that xCyp26c plays a critical role in the specification of anterior neural tissue in whole embryos. In animal cap explants, however, xCyp26c morpholinos did not alter anterior-to-posterior neural tissue formation. Together, these results suggest that xCyp26c plays a specific role in anterior-posterior (A-P) neural patterning of Xenopus embryos.
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참고문헌 (49)
참고문헌 신청
Abu-Abed, S. / 2001 / The retinoic acid-metabolizing enzyme, Cyp26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures / Genes Dev 15:226~240
Blumberg, B. / 1997 / An essential role for retinoid signaling in anteroposterior neural patterning / Development 124:373~379
Dale, L. / 1992 / Bone morphogenetic protein 4 : a ventralizing factor in early Xenopus development / Development 115:573~585
de Roos, K. / 1999 / Expression of retinoic acid 4-hydroxylase(Cyp26). during mouse and Xenopus laevis embryogenesis / Mech. Dev 82:205~211
Doniach, T. / 1995 / Basic FGF as an inducer of anteroposterior neural pattern / Cell 83:1067~1070
Blumberg, B. / 1997 / An essential role for retinoid signaling in anteroposterior neural patterning / Development 124:373~379
Dale, L. / 1992 / Bone morphogenetic protein 4 : a ventralizing factor in early Xenopus development / Development 115:573~585
de Roos, K. / 1999 / Expression of retinoic acid 4-hydroxylase(Cyp26). during mouse and Xenopus laevis embryogenesis / Mech. Dev 82:205~211
Doniach, T. / 1995 / Basic FGF as an inducer of anteroposterior neural pattern / Cell 83:1067~1070
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