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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 333 - 344 (12page)
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초록· 키워드
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Various genetic and environmental factors are known to be associated with chronic obstructive pulmonary disease (COPD). We identified COPD-related differentially expressed genes (DEGs) using 189 samples accompanying either adenocarcinoma (AC) or squamous cell carcinoma (SC), comprising 91 normal and 98 COPD samples. DEGs were obtained from the intersection of two DEG sets separately identified for AC and SC to exclude the influence of different cancer backgrounds co-occurring with COPD. We also measured patient samples named group ‘I’, which were unable to be determined as normal or COPD based on alterations in gene expression. The Gene Ontology (GO) analysis revealed significant alterations in the expression of genes categorized with the ‘cell adhesion’, ‘inflammatory response’, and ‘mitochondrial functions’, i.e., well-known functions related to COPD, in samples from patients with COPD. Multi-omics data were subsequently integrated to decipher the upstream regulatory changes linked to the gene expression alterations in COPD. COPD-associated expression quantitative trait loci (eQTLs) were located at the upstream regulatory regions of 96 DEGs. Additionally, 45 previously identified COPD-related miRNAs were predicted to target 66 of the DEGs. The eQTLs and miRNAs might affect the expression of ‘respiratory electron transport chain’ genes and ‘cell proliferation’ genes, respectively, while both eQTLs and miRNAs might affect the expression of ‘apoptosis’ genes. We think that our present study will contribute to our understanding of the molecular etiology of COPD accompanying lung cancer.
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참고문헌 (47)
참고문헌 신청
Aaron, S. D. / 2007 / Tiotropium in combination with placebo, salmeterol, or fluticasone–salmeterol for treatment of chronic obstructive pulmonary disease : a randomized trial / Ann. Intern. Med 146:545~555
Agustí, A. / 2012 / Persistent systemic inflammation is associated with poor clinical outcomes in COPD : a novel phenotype / PloS One 7:e37483
Anderson, G. P. / 2003 / Acquired somatic mutations in the molecular pathogenesis of COPD / Trends Pharmacol. Sci 24:71~76
Artigas, M. S. / 2011 / Genome-wide association and large-scale follow up identifies 16new loci influencing lung function / Nat. Genet 43:1082
Barnett, M. / 2005 / Chronic obstructive pulmonary disease : a phenomenological study of patients’ experiences / J. Clin. Nurs 14:805~812
Agustí, A. / 2012 / Persistent systemic inflammation is associated with poor clinical outcomes in COPD : a novel phenotype / PloS One 7:e37483
Anderson, G. P. / 2003 / Acquired somatic mutations in the molecular pathogenesis of COPD / Trends Pharmacol. Sci 24:71~76
Artigas, M. S. / 2011 / Genome-wide association and large-scale follow up identifies 16new loci influencing lung function / Nat. Genet 43:1082
Barnett, M. / 2005 / Chronic obstructive pulmonary disease : a phenomenological study of patients’ experiences / J. Clin. Nurs 14:805~812
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