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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 762 - 767 (6page)
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Fasciclin II (FasII), the Drosophila ortholog of neural cell adhesion molecule (NCAM), plays a critical role in synaptic stabilization and plasticity. Although this molecule undergoes constitutive cycling at the synaptic membrane, how its membrane trafficking is regulated to ensure proper synaptic development remains poorly understood. In a genetic screen, we recovered a mutation in Drosophila mical-like that displays an increase in bouton numbers and a decrease in FasII levels at the neuromuscular junction (NMJ). Similar phenotypes were induced by presynaptic, but not postsynaptic, knockdown of mical-like expression. FasII trafficking assays revealed that the recycling of internalized FasII molecules to the cell surface was significantly impaired in mical-like-knockdown cells. Importantly, this defect correlated with an enhancement of endosomal sorting of FasII to the lysosomal degradation pathway. Similarly, synaptic vesicle exocytosis was also impaired in mical-like mutants. Together, our results identify Mical-like as a novel regulator of synaptic growth and FasII endocytic recycling.
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참고문헌 (27)
참고문헌 신청
Bailey, C. H. / 1992 / Serotonin-mediated endocytosis of apCAM : an early step of learning-related synaptic growth in Aplysia / Science 256:645~649
Bailey, C. H. / 1997 / Mutation in the phosphorylation sites of MAP kinase blocks learning-related internalization of apCAM in Aplysia sensory neurons / Neuron 18:913~924
Budnik, V. / 1996 / Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg / Neuron 17:627~640
Bukalo, O. / 2004 / Conditional ablation of the neural cell adhesion molecule reduces precision of spatial learning, long-term potentiation, and depression in the CA1 subfield of mouse hippocampus / J. Neurosci 24:1565~1577
Cremer, H. / 1994 / Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning / Nature 367:455~459
Bailey, C. H. / 1997 / Mutation in the phosphorylation sites of MAP kinase blocks learning-related internalization of apCAM in Aplysia sensory neurons / Neuron 18:913~924
Budnik, V. / 1996 / Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg / Neuron 17:627~640
Bukalo, O. / 2004 / Conditional ablation of the neural cell adhesion molecule reduces precision of spatial learning, long-term potentiation, and depression in the CA1 subfield of mouse hippocampus / J. Neurosci 24:1565~1577
Cremer, H. / 1994 / Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning / Nature 367:455~459
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