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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제46권 제3호
- 발행연도
- 2016.6
- 수록면
- 205 - 220 (16page)
이용수
초록· 키워드
오류제보하기
With the rapid development of biotechnology, various macromolecules as therapeutic agents have made drug delivery an important field of research. However, these are being commercialized as injection form. Due to low patient compliance, various non-invasive routes emerge as a promising strategy. Cell penetrating peptides (CPPs) have shown to assist in efficient and non-toxic manner. They provide ample evidence to deliver of many cargoes ranging from small molecules to proteins and even nanocarriers for various applications. This review briefly discusses about introduction of CPPs, history, cellular uptake mechanisms and various possible alternative routes for CPP-conjugated drug delivery system. It also aims to give a perspective on present status of CPP-mediated research, clinical development, possible obstacles as well as future opportunities. Thus, development of novel CPPs that are safe, tissue-specific and highly efficient will be exemplified and become ideal vehicles for therapeutic delivery in near future.
목차
등록된 정보가 없습니다.
참고문헌 (104)
참고문헌 신청
Abes R. / 2008 / Delivery of steric block morpholino oligomers by(RXR)4 peptides : structure–activity studies / Nucleic Acids Res 36:6343~6354
Bae H. / 2013 / On employing a translationally controlled tumor protein-derived protein transduction domain analog for transmucosal delivery of drugs / J Controlled Release 170:358~364
Baoum A. / 2012 / Calcium condensed cell penetrating peptide complexes offer highly efficient, low toxicity gene silencing / Int J Pharm 427:134~142
Santosh Bashyal / 2015 / Delivery of biopharmaceuticals using combination of liposome and iontophoresis: a review / Journal of Pharmaceutical Investigation 45(7):611~624
Bleifuss E. / 2006 / The translocation motif of hepatitis B virus improves protein vaccination / Cell Mol Life Sci 63:627~635
Bae H. / 2013 / On employing a translationally controlled tumor protein-derived protein transduction domain analog for transmucosal delivery of drugs / J Controlled Release 170:358~364
Baoum A. / 2012 / Calcium condensed cell penetrating peptide complexes offer highly efficient, low toxicity gene silencing / Int J Pharm 427:134~142
Santosh Bashyal / 2015 / Delivery of biopharmaceuticals using combination of liposome and iontophoresis: a review / Journal of Pharmaceutical Investigation 45(7):611~624
Bleifuss E. / 2006 / The translocation motif of hepatitis B virus improves protein vaccination / Cell Mol Life Sci 63:627~635
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