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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제46권 제3호
- 발행연도
- 2016.6
- 수록면
- 273 - 282 (10page)
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초록· 키워드
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Paeoniae Radix, a traditional herbal medicine, has been used in antispasmodic action, alleviating pain, and activating circulation. The aim of this study was to evaluate the pharmacokinetics (PKs) of paeoniflorin in healthy Korean subjects and develop an analytical method for the quantification of paeoniflorin in human plasma. This was an open-label, randomized, and single-dose study in 10 healthy Korean subjects who received a Paeoniae Radix extract powder. The plasma concentration of paeoniflorin up to 12 h was determined using a validated ultra-performance liquid chromatography tandem mass spectrometric method. The PK parameters such as AUC0-?, CL/F, Vd/F, Cmax, Tmax and t1/2 were calculated using WinNonlin software (version 6.4, Pharsight , a CertaraTM Company).
The best PK model of paeoniflorin in humans was the onecompartment model. The mean parameters were 2625.71 L/h, 10,150.55 L, 6.97 ng/mL, and 1.64 h for the oral clearance (CL/F), the volume of distribution (Vd/F), the maximum plasma concentration (Cmax), and the time to reach Cmax(Tmax), respectively. The elimination half-life (t1/2) was 2.68 h. The validated method was successfully applied to the PK study of paeoniflorin in humans. The lower limit of quantification for paeoniflorin in human plasma was 0.2 ng/mL. This study was the first to evaluate the PKs of paeoniflorin after the usual oral dose of Paeoniae Radix extract powder (3.4 g containing 108.18 mg paeoniflorin) in Korean subjects.
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참고문헌 (30)
참고문헌 신청
Ahmad L. / 2015 / Ethnopharmacological documentation of medicinal plants used for hypertension among the local communities of DIR Lower, Pakistan / J Ethnopharmacol 175:138~146
Ai Y. / 2015 / A UPLC-MS/MS method for simultaneous quantitation of three monoterpene glycosides and four alkaloids in rat plasma : application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and single herb extract / J Mass Spectrom 50(3):567~577
Chen YF. / 2013 / Paeonia lactiflora extract attenuating cerebral ischemia and arterial intimal hyperplasia is mediated by paeoniflorin via modulation of VSMC migration and Ras/MEK/ERK signaling pathway / Evid Based Complement Altern Med 2013:482428
Chen J. / 2014 / Development of determination of four analytes of Zhi-Shao-San decoction using LC-MS/MS and its application to comparative pharmacokinetics in normal and irritable bowel syndrome rat plasma / Biomed Chromatogr 28(10):1384~1392
Hu DD. / 2015 / Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS : application in the pharmacokinetic study of Ma-Zi-Ren-Wan / J Chromatogr B Anal Technol Biomed Life Sci 1000:136~146
Ai Y. / 2015 / A UPLC-MS/MS method for simultaneous quantitation of three monoterpene glycosides and four alkaloids in rat plasma : application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and single herb extract / J Mass Spectrom 50(3):567~577
Chen YF. / 2013 / Paeonia lactiflora extract attenuating cerebral ischemia and arterial intimal hyperplasia is mediated by paeoniflorin via modulation of VSMC migration and Ras/MEK/ERK signaling pathway / Evid Based Complement Altern Med 2013:482428
Chen J. / 2014 / Development of determination of four analytes of Zhi-Shao-San decoction using LC-MS/MS and its application to comparative pharmacokinetics in normal and irritable bowel syndrome rat plasma / Biomed Chromatogr 28(10):1384~1392
Hu DD. / 2015 / Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS : application in the pharmacokinetic study of Ma-Zi-Ren-Wan / J Chromatogr B Anal Technol Biomed Life Sci 1000:136~146
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