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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제46권 제4호
- 발행연도
- 2016.7
- 수록면
- 305 - 315 (11page)
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초록· 키워드
오류제보하기
Albumin has been viewed as one of the most useful and versatile carrier proteins in pharmaceutical and clinical fields. Albumin is biocompatible and non-toxic, and so can be used as a pharmaceutical carrier more safely versus many synthetic polymers. Importantly, albumin has great ability to extend circulating half-lives of short-lived peptides and protein drugs when they are properly linked because albumin is hardly filtered in the glomerulus due to its large size (*66.4 kDa). Albumin is also an excellent material to construct nanoparticles because it has good physicochemical stability, targetability, and chemical functionality. In the first part of this review, three major methods for half-life extension of peptide/protein drugs using endogenous or exogenous albumin are described: physical non-covalent binding, covalent binding, and albumin-fusion. The second part details the most intensively utilized methods for nanoparticle preparation: desolvation, nanoparticle albumin bound (NabTM) technology, and self-assembly. The review provides in-depth understanding for albumin-based drugs and their nano-delivery.
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등록된 정보가 없습니다.
참고문헌 (60)
참고문헌 신청
Bae S. / 2012 / Doxorubicin–loaded human serum albumin nanoparticles surface–modified with TNF–related apoptosis–inducing ligand and transferrin for targeting multiple tumor types / Biomaterials 33(5):1536~1546
Baggio LL. / 2008 / An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis / Gastroenterology 134(4):1137~1147
Ballantyne FC. / 1971 / Albumin metabolism in rheumatoid arthritis / Ann Rheum Dis 30(3):265~270
Battogtokh G. / 2015 / Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug / Eur J Pharm Biopharm 96:96~105
Bosse D. / 2005 / Phase I comparability of recombinant human albumin and human serum albumin / J Clin Pharmacol 45(1):57~67
Baggio LL. / 2008 / An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis / Gastroenterology 134(4):1137~1147
Ballantyne FC. / 1971 / Albumin metabolism in rheumatoid arthritis / Ann Rheum Dis 30(3):265~270
Battogtokh G. / 2015 / Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug / Eur J Pharm Biopharm 96:96~105
Bosse D. / 2005 / Phase I comparability of recombinant human albumin and human serum albumin / J Clin Pharmacol 45(1):57~67
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