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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제46권 제5호
- 발행연도
- 2016.8
- 수록면
- 425 - 432 (8page)
이용수
초록· 키워드
오류제보하기
Cholecalciferol, is a fat soluble vitamin D3 (Vit.D3), recognized in promoting bone health in children and adults and also it has other health benefits. Vit.D3 has suggested being dependent on bile salts for the formation of mixed micelles which is a pre requisite for its absorption.
The efficiency of oral absorption of conventional Vit.D3 is approximately 50 %. Arachitol NanoTM is a commercially available nanoparticle based novel drug delivery system (NDDS) of Vit.D3. Data on the uptake of Vit.D3 from the NDDS (Arachitol NanoTM) through the intestinal epithelium is not documented. The aim of the study was to investigate the absorption of a nanoparticle based NDDS of Vit.D3 (Arachitol NanoTM) using everted rat intestinal sac technique. The results of the study suggested that Vit.D3 from Arachitol NanoTM showed a nonspecific absorption through various segments of rat small intestine, with high flux, permeability coefficient and percentage of absorption (79.21 ± 0.23, 76.55 ± 0.24 and 77.73 ± 0.24 % for duodenum, jejunum and ileum). The average absorption of Arachitol NanoTM was 77.83 ± 0.24 % through rat small intestine. The predicted human absorption may be more than 90 %. The study demonstrates that water soluble nanoparticle Vit.D3 (Arachitol NanoTM) can substantially increase the oral absorption of the vitamin D3 and thus can be useful in the oral delivery of vitamin D3.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Animal Research Advisory Committee (ARAC) / Guidelines for euthanasia of rodents using carbon dioxide
Balimane PV. / 2000 / Current methodologies used for evaluation of intestinal permeability and absorption / J Pharmacol Toxicol Methods 44:301~312
Basu TK. / 2003 / Intestinal absorption in health and disease : micronutrients / Best Pract Res Clin Gastroenterol 17:957~979
Bothiraja C. / 2011 / Improved bioavailability of orally administered andrographolide from pH-sensitive nanoparticles / Eur J Drug Metab Ph 35:123~129
Bothiraja C. / 2012 / Novel solvent-free gelucire extract of Plumbago zeylanica using non-everted rat intestinal sac method for improved therapeutic efficacy of plumbagin / J Pharmacol Toxicol Methods 66:35~42
Balimane PV. / 2000 / Current methodologies used for evaluation of intestinal permeability and absorption / J Pharmacol Toxicol Methods 44:301~312
Basu TK. / 2003 / Intestinal absorption in health and disease : micronutrients / Best Pract Res Clin Gastroenterol 17:957~979
Bothiraja C. / 2011 / Improved bioavailability of orally administered andrographolide from pH-sensitive nanoparticles / Eur J Drug Metab Ph 35:123~129
Bothiraja C. / 2012 / Novel solvent-free gelucire extract of Plumbago zeylanica using non-everted rat intestinal sac method for improved therapeutic efficacy of plumbagin / J Pharmacol Toxicol Methods 66:35~42
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