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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제19권 제4호
- 발행연도
- 2015.7
- 수록면
- 327 - 334 (8page)
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초록· 키워드
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The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1 in the angiogenic activity of orexin-A. We showed that orexin-A stimulates expression and activity of HO-1 in human umbilical vein endothelial cells (HUVECs). Furthermore, we showed that inhibition of HO-1 by tin (Sn) protoporphryin-IX (SnPP) reduced orexin- A-induced angiogenesis in vivo and ex vivo. Orexin-A-stimulated endothelial tube formation and chemotactic activity were also blocked in SnPP-treated vascular endothelial cells. Orexin-A treatment increased the expression of nuclear factor erythroid-derived 2 related factor 2 (Nrf2), and antioxidant response element (ARE) luciferase activity, leading to induction of HO-1. Collectively, these findings indicate that HO-1 plays a role as an important mediator of orexin-A-induced angiogenesis, and provide new possibilities for therapeutic approaches in pathophysiological conditions associated with angiogenesis.
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참고문헌 (35)
참고문헌 신청
de Lecea L / 1998 / The hypocretins : hypothalamus-specific peptides with neuroexcitatory activity / Proc Natl Acad Sci U S A 95:322~327
Sakurai T / 1998 / Orexins and orexin receptors : a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior / Cell 92:573~585
Sutcliffe JG / 2000 / The hypocretins : excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding / J Neurosci Res 62:161~168
Jochem J / 2006 / Cardiovascular effects of centrally acting orexin A in haemorrhage-shocked rats / J Physiol Pharmacol 57(Suppl 11):115~124
Tanida M / 2006 / Dose-different effects of orexin-A on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats / Exp Biol Med(Maywood) 231:1616~1625
Sakurai T / 1998 / Orexins and orexin receptors : a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior / Cell 92:573~585
Sutcliffe JG / 2000 / The hypocretins : excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding / J Neurosci Res 62:161~168
Jochem J / 2006 / Cardiovascular effects of centrally acting orexin A in haemorrhage-shocked rats / J Physiol Pharmacol 57(Suppl 11):115~124
Tanida M / 2006 / Dose-different effects of orexin-A on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats / Exp Biol Med(Maywood) 231:1616~1625
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