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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제2호
- 발행연도
- 2016.3
- 수록면
- 153 - 160 (8page)
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초록· 키워드
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The objective was to investigate the hypoglycemic action of catalpol in spontaneous diabetes db/db mice. 40 db/db mice were randomly divided into fi ve groups: model control gourp; db/db plus catalpol 40, 80, 120 mg/kg body wt. groups and db/db plus metformin 250 mg/kg group. Age-matched db/m mice were selected as normal control group. The mice were administered with corresponding drugs or solvent by gavage for 4 weeks. The oral glucose tolerance test was carried out at the end of 3rd week. After 4 weeks of treatment, the concentrations of fasting blood glucose (FBG), glycated serum protein (GSP), insulin (INS), triglyceride (TG), total cholesterol (TC) and adiponection (APN) in serum were detected. The protein expressions of phosphorylation-AMPKα1/2 in liver, phosphorylation-AMPKα1/2 and glucose transporter-4 (GLUT-4) in skeletal muscle and adipose tissues were detected by western blot. Real time RT-PCR was used to detect the mRNA expressions of acetyl-CoA carboxylase (ACC) and Hydroxymethyl glutaric acid acyl CoA reductase (HMGCR) in liver. Our results showed that catalpol could significantly improve the insulin resistance, decrease the serum concentrations of INS, GSP, TG, and TC. The concentrations of APN in serum, the protein expression of phosphorylation- AMPKα1/2 in liver, phosphorylation-AMPKα1/2 and GLUT-4 in peripheral tissue were increased. Catalpol could also down regulate the mRNA expressions of ACC and HMGCR in liver. In conclusion, catalpol ameliorates diabetes in db/db mice. It has benefi t effects against lipid/glucose metabolism disorder and insulin resistance. The mechanism may be related to up-regulating the expression of phosphorylation- AMPKα1/2.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Jiménez-Flores LM / 2014 / A PPARγ, NF-κB and AMPK-dependent mechanism may be involved in the beneficial effects of curcumin in the diabetic db/db mice liver / Molecules 19:8289~8302
Chiang CK / 2007 / Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection : effectiveness and side effects / Diabetes Care 30:3~7
Wang Z / 2013 / Treating type 2 diabetes mellitus with traditional chinese and Indian medicinal herbs / Evid Based Complement Alternat Med 2013:343594
Pungitore CR / 2004 / Inhibition of Taq DNA polymerase by catalpol / Cell Mol Biol(Noisy-le-grand) 50:767~772
Wei M / 2014 / Ovarian failure-resistant effects of catalpol in aged female rats / Biol Pharm Bull 37:1444~1449
Chiang CK / 2007 / Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection : effectiveness and side effects / Diabetes Care 30:3~7
Wang Z / 2013 / Treating type 2 diabetes mellitus with traditional chinese and Indian medicinal herbs / Evid Based Complement Alternat Med 2013:343594
Pungitore CR / 2004 / Inhibition of Taq DNA polymerase by catalpol / Cell Mol Biol(Noisy-le-grand) 50:767~772
Wei M / 2014 / Ovarian failure-resistant effects of catalpol in aged female rats / Biol Pharm Bull 37:1444~1449
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