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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 467 - 483 (17page)
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Objective: This study was performed to investigate the effect of IUS (Inulsan, an extract of Artemisiae capillaris (茵蔯), Curcumae longae (鬱金), and Crataegi fructus (山査)) on anti-hyperlipidemia, anti-oxidation, and anti-inflammation.
Method: We administered water extracts of Artemisiae capillaris, Curcumae longae, and Crataegi fructus for three weeks to db/db mice (C57BL/Ks), animal models induced with type 2 diabetes mellitus. Mice were divided into three groups: normal (C57BL/6J mice group), control group (db/db mice without administration of IUS) and IUS group (db/db mice treated with IUS). Then we measured total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride in the serum after the oral administration of IUS.
Results: 1. IUS did not show any cytotoxicity in RAW 264.7 cells.
2. IUS decreased AST, ALP, and creatinine levelsand did not show any liver or renal toxicity in the db/db mice.
3. IUS increased DPPH and ABTS radical scavenging activity and decreased ROS production in RAW 264.7 cells.
4. IUS significantly decreased IL-1β, IL-6, and TNF-α production in RAW 264.7 cells.
5. IUS increased HDL cholesterol and significantly decreased total cholesterol and triglyceride in db/db mice.
6. IUS significantly decreased the atherogenic index and cardiac risk factor.
7. In contrast with the control group, fat infiltration in the liver and aorta decreased in IUS treated mice. The cell nucleus was located in the central area in H&E staining of liver. And endomembranes also were more thinner than the control group in H&E staining of aorta.
Conclusions: These results suggest that IUS might be effective in the prevention and treatment of dyslipidemia.
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참고문헌 (42)
참고문헌 신청
Statistics Korea / 2014 / Death statistics in Korea / Korea development institute
National Oriental Medical Department of Heart Internal Medicine / 2010 / Circulation of Internal Medicine nerve / Gunja publishing company :169~173
Department of internal medicine. Seoul national university college of medicine / 2014 / SNUH manual of medicine / Korean medical publisher :91~99
Korean stroke society / 2013 / Textbook of Stroke / E+ public :47~51
Assmann G / 1988 / The Prospective Cardiovascular Münster(PROCAM) study:prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease / American heart journal 116(6):1713~1724
National Oriental Medical Department of Heart Internal Medicine / 2010 / Circulation of Internal Medicine nerve / Gunja publishing company :169~173
Department of internal medicine. Seoul national university college of medicine / 2014 / SNUH manual of medicine / Korean medical publisher :91~99
Korean stroke society / 2013 / Textbook of Stroke / E+ public :47~51
Assmann G / 1988 / The Prospective Cardiovascular Münster(PROCAM) study:prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease / American heart journal 116(6):1713~1724
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