지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 456 - 462 (7page)
이용수
초록· 키워드
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Background: Abnormal activation of matrix metalloproteinases (MMPs) plays an important role in UV-induced wrinkle formation, which is amajor dermatological problem. This formation occurs due to the degeneration of the extracellular matrix (ECM). In this study, we investigated the cutaneous photoprotective effects of Ultraflo L treated ginseng leaf (UTGL) in hairless mice.
Methods: SKH-1 hairless mice (6 weeks of age) were randomly divided into four groups (8 mice/group). UTGL formulation was applied topically to the skin of the mice for 10 weeks. The normal control group received nonvehicle and was not irradiated with UVB. The UV control (UVB) group received nonvehicle and was exposed to gradient-UVB irradiation. The groups (GA) receiving topical application of UTGL formulation were subjected to gradient-UVB irradiation on 0.5 mg/㎠ [GA-low (GA-L)] and 1.0 mg/㎠ [(GA-high (GA-H)] of dorsal skin area, respectively.
Results: We found that topical treatment with UTGL attenuated UVB-induced epidermal thickness and impairment of skin barrier function. Additionally, UTGL suppressed the expression of MMP-2, -3, and -13 induced by UVB irradiation. Our results show that topical application of UTGL protects the skin against UVB-induced damage in hairless mice and suggest that UTGL can act as a potential agent for preventing and/or treating UVB-induced photoaging.
Conclusion: UTGL possesses sunscreen properties and may exhibit photochemoprotective activities inside the skin of mice. Therefore, UTGL could be used as a potential therapeutic agent to protect the skin against UVB-induced photoaging.
Methods: SKH-1 hairless mice (6 weeks of age) were randomly divided into four groups (8 mice/group). UTGL formulation was applied topically to the skin of the mice for 10 weeks. The normal control group received nonvehicle and was not irradiated with UVB. The UV control (UVB) group received nonvehicle and was exposed to gradient-UVB irradiation. The groups (GA) receiving topical application of UTGL formulation were subjected to gradient-UVB irradiation on 0.5 mg/㎠ [GA-low (GA-L)] and 1.0 mg/㎠ [(GA-high (GA-H)] of dorsal skin area, respectively.
Results: We found that topical treatment with UTGL attenuated UVB-induced epidermal thickness and impairment of skin barrier function. Additionally, UTGL suppressed the expression of MMP-2, -3, and -13 induced by UVB irradiation. Our results show that topical application of UTGL protects the skin against UVB-induced damage in hairless mice and suggest that UTGL can act as a potential agent for preventing and/or treating UVB-induced photoaging.
Conclusion: UTGL possesses sunscreen properties and may exhibit photochemoprotective activities inside the skin of mice. Therefore, UTGL could be used as a potential therapeutic agent to protect the skin against UVB-induced photoaging.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (34)
참고문헌 신청
[학술지(정기간행물)] - Fisher GJ / 1996 / Molecular basis of sun-induced premature skin ageing and retinoid antagonism / Nature 379 : 335 ~ 339
[학술지(정기간행물)] - Gilchrest BA / 1996 / Mechanisms of ultraviolet lightinduced pigmentation / Photochem Photobiol 63 : 1 ~ 10
[학술지(정기간행물)] - Beissert S / 1999 / Mechanisms involved in ultraviolet light-induced immunosuppression / J Investig Dermatol Symp Proc 4 : 61 ~ 64
[학술지(정기간행물)] - Afaq F / 2005 / Photochemoprevention of ultraviolet B signaling and photocarcinogenesis / Mutat Res-Fundam Mol Mech Mutag 571 : 153 ~ 173
[학술지(정기간행물)] - Sternlicht MD / 2001 / How matrix metalloproteinases regulate cell behavior / Annu Rev Cell Dev Biol 17 : 463 ~ 516
[학술지(정기간행물)] - Gilchrest BA / 1996 / Mechanisms of ultraviolet lightinduced pigmentation / Photochem Photobiol 63 : 1 ~ 10
[학술지(정기간행물)] - Beissert S / 1999 / Mechanisms involved in ultraviolet light-induced immunosuppression / J Investig Dermatol Symp Proc 4 : 61 ~ 64
[학술지(정기간행물)] - Afaq F / 2005 / Photochemoprevention of ultraviolet B signaling and photocarcinogenesis / Mutat Res-Fundam Mol Mech Mutag 571 : 153 ~ 173
[학술지(정기간행물)] - Sternlicht MD / 2001 / How matrix metalloproteinases regulate cell behavior / Annu Rev Cell Dev Biol 17 : 463 ~ 516
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UCI(KEPA) : I410-ECN-0101-2018-524-001599206