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Structure and nuclear transport mechanism of HSP70 nuclear transporter, Hikeshi
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국구조생물학회 Biodesign Biodesign 제3권 제3호 KCI등재후보
- 발행연도
- 2015.9
- 수록면
- 117 - 122 (6page)
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Translocation of macromolecules across the nuclear membrane under the normal conditions has been well studied,but the mechanism of nuclear translocation under the heat-shock stress conditions remain elusive. Hikeshi is a nucleartransport receptor required for cell survival after heat-shock stress. It is in charge of heat shock-induced nuclear import of70-kilodalton heat shock proteins (HSP70s) through interactions with FG repeats in nuclear pore complexes. Hikeshi formsan “asymmetric” homodimer that is a characteristic feature. Asymmetry of Hikeshi arises from the distinct conformationof the C-terminal domain and the flexibility of the linker regions which areas are essential for nuclear import of HSP70.
A unique extended-loop (E-loop) in the N-terminal domain controls the interactions of Hikeshi with FG-Nups by openingor closing the F97 binding site. The recently reported X-ray structure of Hikeshi explains how Hikeshi participates in thenuclear import regulation through FG-Nups recognition, and which part of Hikeshi affects its binding to HSP70. In thisreview, we will discuss the structural insight on the highly unique import receptor Hikeshi in heat-shock stress condition.
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참고문헌 (32)
참고문헌 신청
Chang, Y. W. / 2008 / Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation / J Biol Chem 283:15502~15511
Choi, S. / 2014 / Structural basis for the selective nuclear import of the C2H2zinc-finger protein Snail by importin β / Acta Cryst D 70:1050~1060
Chothia, C. / 1981 / Helix to helix packing in proteins / J Mol Biol 145:215~250
Cingolani, G. / 2002 / Molecular basis for the recognition of a nonclassical nuclear localization signal by importin β / Mol Cell 10:1345~1353
Ellis, R. J. / 1991 / Molecular chaperones / Annu Rev Biochem 60:321~347
Choi, S. / 2014 / Structural basis for the selective nuclear import of the C2H2zinc-finger protein Snail by importin β / Acta Cryst D 70:1050~1060
Chothia, C. / 1981 / Helix to helix packing in proteins / J Mol Biol 145:215~250
Cingolani, G. / 2002 / Molecular basis for the recognition of a nonclassical nuclear localization signal by importin β / Mol Cell 10:1345~1353
Ellis, R. J. / 1991 / Molecular chaperones / Annu Rev Biochem 60:321~347
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