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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Currently, many strains of influenza A virus have developed resistance against anti-influenza drugs, and it is essential tofind new chemicals to combat this virus. The viral nucleoprotein (NP) is a major component of the ribonucleoprotein (RNP)complex for the transcription and replication of the virus. In this study, we have employed surface plasmon resonancedirect binding screening on the influenza A NP and found a hit compound 16 that can subdue influenza RNP activities.
Subsequently, two analogs (compounds 55 & 58) from compound 16 were identified which inhibit RNP activities of variousinfluenza A subtypes and viral growth at micromolar levels. These analogs were also shown to directly interact with NP,with KD 12.0±1.25 and 41.6±1.93 μM respectively by surface plasmon resonance assay.
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참고문헌 (22)
참고문헌 신청
Amorim, M. J. / 2013 / Nucleozin targets cytoplasmic trafficking of vRNP-Rab11 complexes in influenza A virus infection / J Virol 87:4694~4703
Chen, H. / 2009 / Oseltamivir-resistant influenza A pandemic(H1N1)2009 virus, Hong Kong, China / Emerging Infect Dis 15:1970~1972
Elinder, M. / 2009 / Screening for NNRTIs with slow dissociation and high affinity for a panel of HIV-1 RT variants / J Biomol Screening 14:395~403
Fodor, E. / 2002 / A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs / J Virol 76:8989~9001
Fodor, E. / 1999 / Rescue of influenza A virus from recombinant DNA / J Virol 73:9679~9682
Chen, H. / 2009 / Oseltamivir-resistant influenza A pandemic(H1N1)2009 virus, Hong Kong, China / Emerging Infect Dis 15:1970~1972
Elinder, M. / 2009 / Screening for NNRTIs with slow dissociation and high affinity for a panel of HIV-1 RT variants / J Biomol Screening 14:395~403
Fodor, E. / 2002 / A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs / J Virol 76:8989~9001
Fodor, E. / 1999 / Rescue of influenza A virus from recombinant DNA / J Virol 73:9679~9682
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