지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.7
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- 81 - 92 (12page)
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이 논문의 연구 히스토리 (3)
2020
Comparison of the presentation of atopic dermatitis induced by trinitrochlorobenzene and house dust mite in NC/Nga mice
Yoon-Hwan Kim
,
Tae Hyeong Kim
,
Min Soo Kang
외 3명
Journal of Veterinary Science
2020.07
학술저널
Anti-Inflammatory and immune modulatory effects of Synbio-glucan in house dust mite model with NC/Nga mice
Yoon-Hwan Kim
,
Tae Hyeong Kim
,
Min Soo Kang
외 3명
한국실험동물학회 학술발표대회 논문집
2020.07
학술대회자료
Comparison of Atopic Dermatitis induced by Trinitrochlorobenzene and House Dust Mite in NC/Nga mice
Yoon-Hwan Kim
,
Tae Hyeong Kim
,
Min Soo Kang
외 3명
한국실험동물학회 학술발표대회 논문집
2020.07
학술대회자료
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초록· 키워드
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Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. To understand AD, there have been many trials establishing AD animal models. Although various trials to establish AD animal models have been existed, even the mechanisms of AD in animal models are not enough clarified.
Objectives: This study assessed AD characteristics induced in Nishiki-nezumi Cinnamon/Nagoya (Nc/Nga) mice following trinitrochlorobenzene (TNCB) treatment for different periods and house dust mite (HDM) treatment to compare each model"s immunological patterns, especially with cytokine antibody array tool.
Methods: In this study, we exposed Nc/Nga mice to TNCB or HDM extract to induce AD. Nc/Nga mice were divided into 4 groups: control, TNCB 2 weeks-treated, TNCB 8 weeks-treated, and HDM-treated groups. After AD induction, all mice were evaluated by serum immunoglobulin E (IgE) concentration and serum cytokine antibody assays, scoring of skin lesions, scoring of scratching frequency, and histological analysis.
Results: The results showed significant differences between groups in serum IgE concentration, skin lesion scores, and scratching frequency. The analysis results for serum cytokine antibody arrays showed that in the TNCB 8 weeks- and HDM-treated groups, but not in the TNCB 2 weeks-treated group, expressions of genes related to the immune response were enriched. Among the histological results, the skin lesions in the HDM-treated group were most similar to those of AD.
Conclusions: We confirmed that immunological pattern of AD mice was markedly different between HDM and TNCB treated groups. In addition, the immunological pattern was quietly different dependent on TNCB treated duration.
Objectives: This study assessed AD characteristics induced in Nishiki-nezumi Cinnamon/Nagoya (Nc/Nga) mice following trinitrochlorobenzene (TNCB) treatment for different periods and house dust mite (HDM) treatment to compare each model"s immunological patterns, especially with cytokine antibody array tool.
Methods: In this study, we exposed Nc/Nga mice to TNCB or HDM extract to induce AD. Nc/Nga mice were divided into 4 groups: control, TNCB 2 weeks-treated, TNCB 8 weeks-treated, and HDM-treated groups. After AD induction, all mice were evaluated by serum immunoglobulin E (IgE) concentration and serum cytokine antibody assays, scoring of skin lesions, scoring of scratching frequency, and histological analysis.
Results: The results showed significant differences between groups in serum IgE concentration, skin lesion scores, and scratching frequency. The analysis results for serum cytokine antibody arrays showed that in the TNCB 8 weeks- and HDM-treated groups, but not in the TNCB 2 weeks-treated group, expressions of genes related to the immune response were enriched. Among the histological results, the skin lesions in the HDM-treated group were most similar to those of AD.
Conclusions: We confirmed that immunological pattern of AD mice was markedly different between HDM and TNCB treated groups. In addition, the immunological pattern was quietly different dependent on TNCB treated duration.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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Comparison of Atopic Dermatitis induced by Trinitrochlorobenzene and House Dust Mite in NC/Nga mice
한국실험동물학회 학술발표대회 논문집
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Anti-Inflammatory and immune modulatory effects of Synbio-glucan in house dust mite model with NC/Nga mice
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A Probiotic Preparation Alleviates Atopic Dermatitis-Like Skin Lesions in Murine Models
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2016 .04
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Retrospective Analysis on the Effects of House Dust Mite Specific Immunotherapy for More Than 3 Years in Atopic Dermatitis
Yonsei Medical Journal
2016 .01
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Oral administration of Sargassum horneri ethanol extract improves atopic dermatitis in house dust mite/DNCB-stimulated NC/Nga mice model
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Chronic Toxoplasmosis Modulates the Induction of Contact Hypersensitivity by TNCB in Mouse Model
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Polyphenol-rich Sargassum horneri alleviates atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th-2 mediated cytokine IL-13
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Topical Application of Eupatilin Ameliorates Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice
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Hataedock Treatments for Dermatophagoides Farinae-induced Atopic Dermatitis in NC/Nga Mice Treated with High-fat Diet
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아토피피부염 환아에서 interleukin-31 및 25-hydroxyvitamin D의 혈청 수치와 아토피피부염의 중증도와의 상관관계
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아토피 피부염 환아의 정신 건강 분석 및 아토피 피부염 교육을 통한 인식, 인지도 개선에 대한 고찰
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Clinical Efficacy of Subcutaneous Allergen Immunotherapy in Patients with Atopic Dermatitis
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