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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 113 - 123 (11page)
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There are differences in opinion regarding the application of external beam radiotherapy in the treatment of hepatocellular carcinoma. Some major guidelines state that external beam radiotherapy is yet to attain a sufficient level of evidence. However, caution should be exercised when attempting to understand the clinical need for external beam radiotherapy solely based on the level of evidence. Previously, external beam radiotherapy had low applicability in the treatment of hepatocellular carcinoma before computed tomography-based planning was popularized. Modern external beam radiotherapy can selectively target tumor cells while sparing normal liver tissues. Recent technologies such as stereotactic body radiotherapy have enabled more precise treatment. The characteristics of hepatocellular carcinoma differ significantly according to the regional etiology. The main cause of hepatocellular carcinoma is the hepatitis B virus. It is commonly diagnosed as a locally advanced tumor but with relatively preserved hepatic function. The majority of these hepatocellular carcinoma cases are found in the East Asian population. Hepatocellular carcinoma caused by hepatitis C virus or other benign hepatitis tends to be diagnosed as a less locally aggressive tumor but with deteriorated liver function. The western world and Japan tend to have patients with such causes. External beam radiotherapy has been more commonly performed for the former, although the use of external beam radiotherapy in the latter might have more concerns with regard to hepatic toxicity. This review discusses the above subjects along with perspectives regarding external beam radiotherapy in recent guidelines.
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참고문헌 (56)
참고문헌 신청
Sung H / 2021 / Global Cancer Statistics 2020 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 71:209~249
Cheung TT / 2018 / Hong Kong consensus statements for the management of unresectable hepatocellular carcinoma / Liver Cancer 7:40~54
조창민 / 2005 / 간세포암종의 치료에 있어 고주파 소작술과 수술적 절제의 비교 / Clinical and Molecular Hepatology 11(2005):59~71
Hung HH / 2011 / Survival rates are comparable after radiofrequency ablation or surgery in patients with small hepatocellular carcinomas / Clin Gastroenterol Hepatol 9:79~86
Llovet JM / 2003 / Systematic review of randomized trials for unresectable hepatocellular carcinoma : chemoembolization improves survival / Hepatology 37:429~442
Cheung TT / 2018 / Hong Kong consensus statements for the management of unresectable hepatocellular carcinoma / Liver Cancer 7:40~54
조창민 / 2005 / 간세포암종의 치료에 있어 고주파 소작술과 수술적 절제의 비교 / Clinical and Molecular Hepatology 11(2005):59~71
Hung HH / 2011 / Survival rates are comparable after radiofrequency ablation or surgery in patients with small hepatocellular carcinomas / Clin Gastroenterol Hepatol 9:79~86
Llovet JM / 2003 / Systematic review of randomized trials for unresectable hepatocellular carcinoma : chemoembolization improves survival / Hepatology 37:429~442
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