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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 169 - 176 (8page)
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The current Food and Drug Administration-approved systemic treatments for advanced hepatocellular carcinoma (HCC) include multikinase inhibitors (tyrosine kinase inhibitor [TKI]) and immune checkpoint inhibitors (ICIs). Among ICIs, nivolumab is used as second?line therapy for advanced HCC after sorafenib failure or patient intolerance. In this case, a patient with infiltrative HCC and portal vein tumor thrombosis was treated with hepatic arterial infusion chemotherapy (HAIC) and radiation therapy. New lung metastasis developed after HAICs; thus, lenvatinib treatment was initiated. However, the disease progressed. Thereafter, sorafenib treatment was initiated but he developed intolerance, with grade 3 sorafenib-related diarrhea. Subsequently, nivolumab was administered as rescue therapy. He demonstrated a partial response to nivolumab after the third treatment and viable HCCs in the lungs and liver completely disappeared after the 24th treatment. These findings suggest that nivolumab could be used as an effective rescue therapy for advanced HCC progression after TKI treatment.
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참고문헌 (20)
참고문헌 신청
Akinyemiju T / 2017 / The burden of primary liver cancer and underlying etiologies from 1990 to 2015at the global, regional, and national level: results from the global burden of disease study 2015 / JAMA Oncol 3:1683~1691
Kanwal F / 2017 / Risk of hepatocellular cancer in HCV patients treated with direct-acting antiviral agents / Gastroenterology 153:996~1005
Llovet JM / 2021 / Hepatocellular carcinoma / Nat Rev Dis Primers 7:6
Sun Young Yim / 2019 / The Genomic Landscape and Its Clinical Implications in Hepatocellular Carcinoma / Journal of Liver Cancer 19(2):97~107
Choi JH / 2018 / Randomized, prospective, comparative study on the effects and safety of sorafenib vs. hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma with portal vein tumor thrombosis / Cancer Chemother Pharmacol 82:469~478
Kanwal F / 2017 / Risk of hepatocellular cancer in HCV patients treated with direct-acting antiviral agents / Gastroenterology 153:996~1005
Llovet JM / 2021 / Hepatocellular carcinoma / Nat Rev Dis Primers 7:6
Sun Young Yim / 2019 / The Genomic Landscape and Its Clinical Implications in Hepatocellular Carcinoma / Journal of Liver Cancer 19(2):97~107
Choi JH / 2018 / Randomized, prospective, comparative study on the effects and safety of sorafenib vs. hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma with portal vein tumor thrombosis / Cancer Chemother Pharmacol 82:469~478
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A Case of Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis Treated by Hepatic Arterial Infusion Chemotherapy and Radiotherapy
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Combination Therapy of Angiotherapy, Radiation Therapy, and Radiofrequency Ablation for Pulmonary Metastasis of Hepatocellular Carcinoma Accompanied by Nontuberculous Mycobacteria
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Extraordinary radiation super-sensitivity accompanying with sorafenib combination therapy: what lies beneath?
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Current role of proton beam therapy in patients with hepatocellular carcinoma
International Journal of Gastrointestinal Intervention
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Recent advances in the management of hepatocellular carcinoma
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Current Trends and Recent Advances in Diagnosis, Therapy, and Prevention of Hepatocellular Carcinoma
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