지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.5
- 수록면
- 138 - 147 (10page)
이용수
초록· 키워드
오류제보하기
Toxoplasma gondii is an intracellular protozoan parasite which can infect most warmblooded animals and humans. Among the different mouse models, C57BL/6 mice are more susceptible to T. gondii infection compared to BALB/c mice, and this increased susceptibility has been attributed to various factors, including T-cell responses. Dendritic cells (DCs) are the most prominent type of antigen-presenting cells and regulate the host immune response, including the response of T-cells. However, differences in the DC responses of these mouse strains to T. gondii infection have yet to be characterized. In this study, we cultured bone marrow-derived DCs (BMDCs) from BALB/c and C57BL/6 mice. These cells were infected with T. gondii. The activation of the BMDCs was assessed based on the expression of cell surface markers and cytokines. In the BMDCs of both mouse strains, we detected significant increases in the expression of cell surface Tcell co-stimulatory molecules (major histocompatibility complex (MHC) II, CD40, CD80, and CD86) and cytokines (tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-12p40, IL-1β, and IL-10) from 3 h post-T. gondii infection. The expression of MHC II, CD40, CD80, CD86, IFN-γ, IL-12p40, and IL-1β was significantly higher in the T. gondiiinfected BMDCs obtained from the C57BL/6 mice than in those from the BALB/c mice. These findings indicate that differences in the activation status of the BMDCs in the BALB/c and C57BL/6 mice may account for their differential susceptibility to T. gondii.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The detection of Toxoplasma gondii ME49 infections in BALB/c mice using various techniques
Parasites, Hosts and Diseases
2023 .11
-
A halophyte modulate cytokine responses induced by Toxoplasma gondii infection in mouse
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Inhibitory Effect of WK03 extract on Proinflammatory Cytokines Production in infection of Toxoplasma (T.) gondii
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Immune Responses Induced by HSP60 DNA Vaccine against Toxoplasma gondii Infection in Kunming Mice
Parasites, Hosts and Diseases
2018 .06
-
The Role of PI3K/AKT Pathway and NADPH Oxidase 4 in Host ROS Manipulation by Toxoplasma gondii
Parasites, Hosts and Diseases
2020 .06
-
Anti-tumor effects of Toxoplasma gondii and antigen-pulsed dendritic cells in mice bearing breast cancer
Parasites, Hosts and Diseases
2025 .02
-
Previous Infection with Plasmodium berghei Confers Resistance to Toxoplasma gondii Infection in Mice
Parasites, Hosts and Diseases
2019 .04
-
Detection of Toxoplasma gondii Infections using Virus-Like Particles Displaying T. gondii ROP4 Antigen
Parasites, Hosts and Diseases
2021 .12
-
Virus-like Particle Vaccine Containing Toxoplasma gondii Rhoptry Protein 13 Induces Protection against T. gondii ME49 Infection in Mice
Parasites, Hosts and Diseases
2019 .10
-
Exosomes Secreted by Toxoplasma gondii-Infected L6 Cells : Their Effects on Host Cell Proliferation and Cell Cycle Changes
Parasites, Hosts and Diseases
2016 .04
-
IL-12 and IL-23 Production in Toxoplasma gondii- or LPS-Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways
Parasites, Hosts and Diseases
2017 .12
-
Toxoplasma gondii Induces Apoptosis via Endoplasmic Reticulum Stress-Derived Mitochondrial Pathway in Human Small Intestinal Epithelial Cell-Line
Parasites, Hosts and Diseases
2021 .12
-
Neuroprotective Effect of Chronic Intracranial Toxoplasma gondii Infection in a Mouse Cerebral Ischemia Model
Parasites, Hosts and Diseases
2020 .08
-
Molecular epidemiology of Toxoplasma gondii in cattle in Korea
Parasites, Hosts and Diseases
2023 .05
-
Sequence Diversity in MIC6 Gene among Toxoplasma gondii Isolates from Different Hosts and Geographical Locations
Parasites, Hosts and Diseases
2015 .06
-
A Salmonella Typhi ghost induced by the E gene of phage φX174 stimulates dendritic cells and efficiently activates the adaptive immune response
Journal of Veterinary Science
2018 .07
-
Production of Inflammatory Cytokines and Nitric Oxide by Human Mast Cells Incubated with Toxoplasma gondii Lysate
Parasites, Hosts and Diseases
2019 .04
-
Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
Parasites, Hosts and Diseases
2021 .06
-
Immunogenicity of Exosomes from Dendritic Cells Stimulated with Toxoplasma gondii Lysates in Ocularly Immunized Mice
Parasites, Hosts and Diseases
2020 .04
-
Evaluation of Protective Immune Response Induced by a DNA Vaccine Encoding GRA8 against Acute Toxoplasmosis in a Murine Model
Parasites, Hosts and Diseases
2018 .08
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-513-001473081