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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Chigeru Wodi (Ebonyi State University) Ebere Ezaka (Ebonyi State University) Boniface N. Ukwah (Ebonyi State University) Ukpai A. Eze (De Montfort University)
저널정보
환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.38 No.2
발행연도
2023.6
수록면
75 - 86 (12page)

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초록· 키워드

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The use of home remedies for medicinal purposes, most of which are edible plants has continued to be a practice in many homes. However, there has been an increasing report of chronic use with lethal effect. Among the commonly used herbal/ medicinal plants were ginger, garlic and lemon. These were seen to be prevalent across continents with brewing and crude extraction being the most means of consumption. This study investigated the organ wide toxicity of this extract following chronic consumption of crude extract. Twenty-five albino Wister rats, five in each group were used for this experiment. Each animal received 0.5ml/kg body weight of either ginger extract, garlic extract, lemon juice, or a mixture of equal volumes of all three extract (v/v) respectively twice daily for seven (7) days. Statistics were represented as ±SE; P≤0.05 was considered significant. Previous studies have shown that moderate consumption of these medicinal plants were beneficial and have shown no deleterious effect. This study observed no change in the weight of the experimental animals. The weight of the animals continued to increase except for the group that received lemon and the mixture, but these were not significant. It was observed that chronic consumption induced organ wide toxicity to include the liver, kidney, intestinal epithelium, stomach, and pancreas. These were shown to alter tissue architecture and the cell morphology. Packed cell volume was reduced in the lemon and the group that received a combination of all extracts (p=o.03). Blood differentials showed changes in levels. An elevated basophil level was observed in ginger and garlic (p<0.0001; p=0.0006). Monocyte levels increased progressively across each group when compared to the control with the most elevated level seen in the group that received the mixture (p<0.0001). Lymphocyte count was reduced across all the groups that received the extract except for animals that received ginger. This study suggests the application of caution among users of these medicinal plants and continues to draw attention to the need for harmonization and standardization of safe use doses.
#medicinal plants #home remedies #herbal formulation #organ toxicity

목차

Abstract
Introduction
Materials and Methods
Results
Discussion
Conclusions
References

참고문헌 (49)

참고문헌 신청
Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci 2005;78(5):431-441. https://doi.org/10.1016/j.lfs.2005.09.012 google schola Chen SL, Yu H, Luo HM, Wu Q, Li CF, Steinmetz A. Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med 2016;11:37. https://doi.org/10.1186/s13020-016-0108-7 google schola Braun LA, Tiralongo E, Wilkinson JM, Spitzer O, Bailey M, Poole S, et al. Perceptions, use and attitudes of pharmacy customers on complementary medicines and pharmacy practice. BMC Compliment Altern Med 2010;10:38. https://doi.org/10.1186/1472-6882-10-38 google schola Anquez-Traxler C. The legal and regulatory framework of herbal medicinal products in the European Union: A focus on the traditional herbal medicines category. Drug Information Journal 2011;45(1):15-23. https://doi.org/10.1177/009286151104500102 google schola Martins E. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014;4:177. https://doi.org/10.3389/fphar.2013.00177 google schola

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